Differential acute postprandial effects of processed meat and isocaloric vegan meals on the gastrointestinal hormone response in subjects suffering from type 2 diabetes and healthy controls: a randomized crossover study
Belinova L, Kahleova H, Malinska H, Topolcan O, Vrzalova J, Oliyarnyk O, Kazdova L, Hill M, Pelikanova T
PloS one · 36 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Univerzita Karlova v Praze
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-09-15 · PLoS One · vol. 9 · número 9 · pág. e107561
- Editorial
- Public Library of Science
- Citado
- 47 citas · más que el 73% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Regulation of Appetite and Obesity · Diet and metabolism studies · Nutritional Studies and Diet
- Palabras clave
- Postprandial, Internal medicine, Crossover study, Meal, Type 2 diabetes, Medicine, Endocrinology, Insulin, Diabetes mellitus, Incretin, Placebo
- MeSH
- humans, diabetes mellitus, type 2, gastrointestinal hormones, gastric inhibitory polypeptide, insulin, blood glucose, lipids, triglycerides, postprandial period, food handling, meat, middle aged, female, male, glucagon-like peptide 1, ghrelin, diet, vegan
9 autores
- Lenka Belinova🇨🇿 · autor de correspondenciaCharles University; Institute of Clinical and Experimental Medicine
- Hana Kahleová🇨🇿Institute of Clinical and Experimental Medicine
- Hana Malínská🇨🇿Institute of Clinical and Experimental Medicine
- Ondřej Topolčan
- Jindra Vrzalová
- Olena Oliyarnyk🇨🇿Institute of Clinical and Experimental Medicine
- Ludmila Kazdová🇨🇿Institute of Clinical and Experimental Medicine
- Martin Hill🇨🇿Institute of Endocrinology
- Terezie Pelikánová🇨🇿Institute of Clinical and Experimental Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The intake of meat, particularly processed meat, is a dietary risk factor for diabetes. Meat intake impairs insulin sensitivity and leads to increased oxidative stress. However, its effect on postprandial gastrointestinal hormone (GIH) secretion is unclear. We aimed to investigate the acute effects of two standardized isocaloric meals: a processed hamburger meat meal rich in protein and saturated fat (M-meal) and a vegan meal rich in carbohydrates (V-meal). We hypothesized that the meat meal would lead to abnormal postprandial increases in plasma lipids and oxidative stress markers and impaired GIH responses.
Methods
In a randomized crossover study, 50 patients suffering from type 2 diabetes (T2D) and 50 healthy subjects underwent two 3-h meal tolerance tests. For statistical analyses, repeated-measures ANOVA was performed.
Results
The M-meal resulted in a higher postprandial increase in lipids in both groups (p<0.001) and persistent postprandial hyperinsulinemia in patients with diabetes (p<0.001). The plasma glucose levels were significantly higher after the V-meal only at the peak level. The plasma concentrations of glucose-dependent insulinotropic peptide (GIP), peptide tyrosine-tyrosine (PYY) and pancreatic polypeptide (PP) were higher (p<0.05, p<0.001, p<0.001, respectively) and the ghrelin concentration was lower (p<0.001) after the M-meal in healthy subjects. In contrast, the concentrations of GIP, PYY and PP were significantly lower after the M-meal in T2D patients (p<0.001). Compared with the V-meal, the M-meal was associated with a larger increase in lipoperoxidation in T2D patients (p<0.05).
Conclusion/interpretation
Our results suggest that the diet composition and the energy content, rather than the carbohydrate count, should be important considerations for dietary management and demonstrate that processed meat consumption is accompanied by impaired GIH responses and increased oxidative stress marker levels in diabetic patients.
Trial registration
ClinicalTrials.gov NCT01572402.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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