Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis
Chen LW, Wu Y, Neelakantan N, Chong MF, Pan A, van Dam RM
BMC medicine · 90 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-09-19 · BMC Med · vol. 12 · número 1 · pág. 174
- Editorial
- BioMed Central
- Citado
- 147 citas · más que el 87% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 67 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Coffee research and impacts · Prenatal Substance Exposure Effects · Birth, Development, and Health
- Palabras clave
- maternal caffeine intake, pregnancy, low birth weight, dose-response relationship, caffeine consumption, birth weight
- MeSH
- humans, prenatal exposure delayed effects, birth weight, caffeine, risk, prospective studies, pregnancy, infant, newborn, infant, low birth weight, female, male
6 autores
- Ling‐Wei Chen🇸🇬National University of Singapore; National University Health System
- Yi Wu🇸🇬National University of Singapore; National University Health System
- Nithya Neelakantan🇸🇬National University of Singapore; National University Health System
- Mary Foong‐Fong Chong🇸🇬Agency for Science, Technology and Research; National University of Singapore; Singapore Institute for Clinical Sciences; National University Health System; Clinical Nutrition Research Centre
- An Pan🇸🇬National University of Singapore; National University Health System
- Rob M. van Dam🇺🇸🇸🇬Harvard University; National University of Singapore; National University Health System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Considerable controversy exists regarding the relation between maternal caffeine intake during pregnancy and risk of low birth weight (birth weight <2,500 g). We aim to assess this association using a systematic review and dose-response meta-analysis of prospective studies.
Methods
Potential articles were identified by searching MEDLINE and SCOPUS databases through 17 July 2013. Two authors independently extracted information on study design, participant characteristics and estimates of associations. Random-effects models were used to derive the summary relative risks (RRs) and corresponding 95% confidence intervals (CIs). Dose-response relationships were assessed using generalized least-squares trend estimation.
Results
In our meta-analysis, we included 13 prospective studies: 9 with low birth weight as a binary outcome variable (90,747 participants and 6,303 cases) and 6 with birth weight as a continuous outcome variable (10,015 participants; 2 studies reported both types of outcomes). Compared with the reference category with no or very low caffeine intake, the RR (95% CI) of low birth weight was 1.13 (1.06 to 1.21; I 2 0.0%) for low intake (50 to 149 mg/day), 1.38 (1.18 to 1.62; I 2 31.9%) for moderate intake (150 to 349 mg/day), and 1.60 (1.24 to 2.08; I 2 65.8%) for high intake (≥350 mg/day). In the dose-response analysis, each 100-mg/day increment in maternal caffeine intake (around one cup of coffee) was associated with 13% (RR 1.13, 1.06 to 1.21) higher risk of low birth weight. The association persisted in strata defined according to various study characteristics. Moderate (-33 g, 95% CI -63 to -4; I 2 0.3%) and high (-69 g, 95% CI -102 to -35; I 2 0.0%) caffeine intakes were also associated with a significantly lower birth weight as compared with the reference category.
Conclusions
Higher maternal caffeine intake during pregnancy was associated with a higher risk of delivering low birth weight infants. These findings support recommendations to restrict caffeine intake during pregnancy to low levels.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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