Short-term effects of nitrate-rich green leafy vegetables on blood pressure and arterial stiffness in individuals with high-normal blood pressure
Bondonno CP, Liu AH, Croft KD, Ward NC, Yang X, Considine MJ, Puddey IB, Woodman RJ, Hodgson JM
Free radical biology & medicine · 58 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Royal Perth Hospital Medical Research Foundation
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Gobierno
- National Health and Medical Research Council Senior Research Fellowship
- Universidad u hospital
- Royal Perth Hospital Medical Research Foundation Fellowship/UWA
Según 5 financiadores declarados.
Publicación
- Publicado
- 2014-09-28 · Free Radic Biol Med · vol. 77 · págs. 353–362
- Editorial
- Elsevier BV
- Citado
- 84 citas · más que el 96% de estudios similares · 5.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects · Blood Pressure and Hypertension Studies
- Palabras clave
- dietary nitrate, leafy vegetables, nitrate-nitrite-NO pathway, blood pressure, arterial stiffness, high-normal blood pressure, hypertension risk, pulse wave velocity, augmentation index, salivary nitrate, plasma nitrate, nitrite
- MeSH
- humans, spinacia oleracea, hypertension, potassium, sodium, creatinine, treatment outcome, blood pressure, adult, aged, middle aged, female, male, vascular stiffness
9 autores
- Catherine P. Bondonno🇦🇺 · autor de correspondenciaThe University of Western Australia
- Alex H. Liu🇦🇺The University of Western Australia
- Kevin D. Croft🇦🇺The University of Western Australia
- Natalie C. Ward🇦🇺The University of Western Australia
- Xingbin Yang🇦🇺The University of Western Australia
- Michael James Considine🇦🇺🇨🇳Department of Agriculture and Food Western Australia; Shaanxi Normal University
- Ian B. Puddey🇦🇺The University of Western Australia
- Richard John Woodman🇦🇺Flinders University
- Jonathan M. Hodgson🇦🇺The University of Western Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Evidence for a beneficial effect of dietary nitrate, through the nitrate-nitrite-NO pathway, on measures of cardiovascular function in healthy individuals is accumulating. It is less clear whether increased dietary nitrate intake from green leafy vegetables would have similar beneficial vascular effects in those at increased risk of developing hypertension. Our aim was to assess the effects of short-term regular consumption of increased nitrate from green leafy vegetables on blood pressure and arterial stiffness in individuals with high-normal blood pressure. Thirty-eight men and women ages 30-70 years with systolic blood pressure 120 to 139 mm Hg were recruited to a randomized controlled crossover trial. The effects of a 7-day high-nitrate diet intervention (increased nitrate intake by at least 300 mg/day from green leafy vegetables) were compared to a 7-day low-nitrate diet intervention. Outcome measures included pre- and postintervention salivary and plasma nitrate and nitrite concentrations; ambulatory, home, and office blood pressure; augmentation index; and carotid-femoral pulse wave velocity. The high-nitrate diet intervention resulted in at least a fourfold increase in salivary and plasma nitrate and nitrite (P<0.001). Ambulatory, home, and office blood pressure and arterial stiffness were not different between the high-nitrate diet and the low-nitrate diet. Increasing dietary nitrate intake in those with high-normal blood pressure and at increased risk of hypertension may not be an effective short-term strategy to lower blood pressure.
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