A single serving of blueberry (V. corymbosum) modulates peripheral arterial dysfunction induced by acute cigarette smoking in young volunteers: a randomized-controlled trial
Del Bo' C, Porrini M, Fracassetti D, Campolo J, Klimis-Zacas D, Riso P
Food & function · 36 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Fondazione Cariplo
- Subvenciones
- Fondazione Cariplo (Rif. Pratica 2010.2303)
Según 1 financiador declarado.
Publicación
- Publicado
- 2014-01-01 · Food Funct · vol. 5 · número 12 · págs. 3107–3116
- Editorial
- Royal Society of Chemistry
- Citado
- 52 citas · más que el 88% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Phytochemicals and Antioxidant Activities · Nitric Oxide and Endothelin Effects
- Palabras clave
- blueberry, cigarette smoking, peripheral arterial function, reactive hyperemia, arterial stiffness, systolic blood pressure, endothelial dysfunction, oxidative stress, polyphenols, young smokers
- MeSH
- arteries, humans, hyperemia, smoking, oxidative stress, blood pressure, heart rate, adult, male, young adult, volunteers, blueberry plants
6 autores
- Cristian Del Bo’🇮🇹University of Milan
- Marisa Porrini🇮🇹University of Milan
- Daniela Fracassetti🇮🇹University of Milan
- Jonica Campolo🇮🇹Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda; Istituto di Fisiologia Clinica
- Dorothy J. Klimis‐Zacas🇺🇸University of Maine
- Patrizia Riso🇮🇹 · autor de correspondenciaUniversity of Milan
Resumen
El texto original del estudio, en el idioma en que se publicó.
Cigarette smoking causes oxidative stress, hypertension and endothelial dysfunction. Polyphenol-rich foods may prevent these conditions. We investigated the effect of a single serving of fresh-frozen blueberry intake on peripheral arterial function and arterial stiffness in young smokers. Sixteen male smokers were recruited for a 3-armed randomized-controlled study with the following experimental conditions: smoking treatment (one cigarette); blueberry treatment (300 g of blueberry) + smoking; control treatment (300 mL of water with sugar) + smoking. Each treatment was separated by one week of wash-out period. The blood pressure, heart rate, peripheral arterial function (reactive hyperemia and Framingham reactive hyperemia), and arterial stiffness (digital augmentation index, digital augmentation index normalized for a heart rate of 75 bpm) were measured before and 20 min after smoking with Endo-PAT2000. Smoking impaired the blood pressure, heart rate and peripheral arterial function, but did not affect the arterial stiffness. Blueberry consumption counteracted the impairment of the reactive hyperemia index induced by smoking (-4.4 ± 0.8% blueberry treatment vs. -22.0 ± 1.1% smoking treatment, p < 0.01) and Framingham reactive hyperemia (+28.3 ± 19.2% blueberry treatment vs. -42.8 ± 20.0% smoking treatment, p < 0.0001), and the increase of systolic blood pressure (+8.4 ± 0.02% blueberry treatment vs. +13.1 ± 0.02% smoking treatment, mmHg, p < 0.05) after cigarette smoking. No effect was observed for arterial stiffness and other vital signs. In conclusion, data obtained suggest a protective role of blueberry on reactive hyperemia, Framingham reactive hyperemia, and systolic blood pressure in subjects exposed to smoke of one cigarette. Future studies are necessary to elucidate the mechanisms involved.
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