Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study
Ye Z, Sharp SJ, Burgess S, Scott RA, Imamura F, InterAct Consortium, Langenberg C, Wareham NJ, Forouhi NG
The lancet. Diabetes & endocrinology · 147 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wellcome Trust
- Gobierno
- National Institute for Health and Care Research
- Organización sin fines de lucro
- British Heart Foundation
- Gobierno
- European Commission
- Gobierno
- Sixth Framework Programme
- Gobierno
- Medical Research Council
- Gobierno
- UK Medical Research Council (MRC) Epidemiology Unit through programmes
- Gobierno
- National Institute for Health Research (NIHR)
- Gobierno
- European Union Sixth Framework Programme
- Subvenciones
- Medical Research Council (MC_UU_12015/1); Medical Research Council (MC_UU_12015/5); National Institute for Health and Care Research (NF-SI-0512-10165); Medical Research Council (MC_UU_12015/5); Medical Research Council (MC_UU_12015); Medical Research Council (MC_PC_13046); Medical Research Council (MC_PC_13048); Medical Research Council (MR/L003120/1); Wellcome Trust (100114); Medical Research Council (MC_UU_12015/1); British Heart Foundation (RG/08/014/24067); National Institute for Health and Care Research (NF-SI-0512-10135); Sixth Framework Programme (LSHM_CT_2006_037197)
Según 9 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-10-01 · Lancet Diabetes Endocrinol · vol. 3 · número 1 · págs. 35–42
- Editorial
- Elsevier BV
- Citado
- 186 citas · más que el 99% de estudios similares · 14.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Genetic Associations and Epidemiology · Nutrition, Genetics, and Disease
- Palabras clave
- 25-hydroxyvitamin D, vitamin D status, type 2 diabetes, causal relationship, glycemic traits, fasting blood glucose, insulin, HbA1c, DHCR7, CYP2R1, DBP, CYP24A1, vitamin D metabolism genes, single nucleotide polymorphisms, Mendelian randomization
- MeSH
- humans, diabetes mellitus, type 2, vitamin d, incidence, risk factors, polymorphism, single nucleotide, middle aged, female, male, mendelian randomization analysis
8 autores
- Zheng Ye🇬🇧University of Cambridge; MRC Epidemiology Unit
- Stephen J. Sharp🇬🇧University of Cambridge; MRC Epidemiology Unit
- Stephen Burgess🇬🇧University of Cambridge
- Robert A. Scott🇬🇧University of Cambridge; MRC Epidemiology Unit
- Fumiaki Imamura🇬🇧University of Cambridge; MRC Epidemiology Unit
- Claudia Langenberg🇬🇧University of Cambridge; MRC Epidemiology Unit
- Nicholas J. Wareham🇬🇧University of Cambridge; MRC Epidemiology Unit
- Nita G. Forouhi🇬🇧 · autor de correspondenciaUniversity of Cambridge; MRC Epidemiology Unit
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Low circulating concentrations of 25-hydroxyvitamin D (25[OH]D), a marker of vitamin D status, are associated with an increased risk of type 2 diabetes, but whether this association is causal remains unclear. We aimed to estimate the unconfounded, causal association between 25(OH)D concentration and risk of type 2 diabetes using a mendelian randomisation approach.
Methods
Using several data sources from populations of European descent, including type 2 diabetes cases and non-cases, we did a mendelian randomisation analysis using single nucleotide polymorphisms (SNPs) within or near four genes related to 25(OH)D synthesis and metabolism: DHCR7 (related to vitamin D synthesis), CYP2R1 (hepatic 25-hydroxylation), DBP (also known as GC; transport), and CYP24A1 (catabolism). We assessed each SNP for an association with circulating 25(OH)D concentration (5449 non-cases; two studies), risk of type 2 diabetes (28 144 cases, 76 344 non-cases; five studies), and glycaemic traits (concentrations of fasting glucose, 2-h glucose, fasting insulin, and HbA1c; 46 368 non-cases; study consortium). We combined these associations in a likelihood-based mendelian randomisation analysis to estimate the causal association of 25(OH)D concentration with type 2 diabetes and the glycaemic traits, and compared them with that from a meta-analysis of data from observational studies (8492 cases, 89 698 non-cases; 22 studies) that assessed the association between 25(OH)D concentration and type 2 diabetes.
Findings
All four SNPs were associated with 25(OH)D concentrations (p0·25).
Interpretation
The association between 25(OH)D concentration and type 2 diabetes is unlikely to be causal. Efforts to increase 25(OH)D concentrations might not reduce the risk of type 2 diabetes as would be expected on the basis of observational evidence. These findings warrant further investigations to identify causal factors that might increase 25(OH)D concentration and also reduce the risk of type 2 diabetes.
Funding
UK Medical Research Council Epidemiology Unit and European Union Sixth Framework Programme.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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