Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children
Camargo CA, Ganmaa D, Sidbury R, Erdenedelger Kh, Radnaakhand N, Khandsuren B
The Journal of allergy and clinical immunology · 122 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Massachusetts General Hospital
Según 1 financiador declarado.
Publicación
- Publicado
- 2014-10-01 · J Allergy Clin Immunol · vol. 134 · número 4 · págs. 831–835.e1
- Editorial
- Elsevier BV
- Citado
- 171 citas · más que el 100% de estudios similares · 20.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dermatology and Skin Diseases · Vitamin D Research Studies · Contact Dermatitis and Allergies
- Palabras clave
- vitamin D supplementation, atopic dermatitis, vitamin D3, vitamin D deficiency, children, Eczema Area and Severity Index, Investigator's Global Assessment, seasonal exacerbation, Mongolian children
- MeSH
- humans, dermatitis, atopic, disease progression, cholecalciferol, vitamin d, treatment outcome, seasons, dietary supplements, adolescent, child, child, preschool, mongolia, female, male
6 autores
- Carlos A. Camargo🇺🇸 · autor de correspondenciaHarvard University; Massachusetts General Hospital
- Davaasambuu Ganmaa🇺🇸Harvard University; Massachusetts General Hospital
- Robert Sidbury🇺🇸Seattle Children's Hospital
- Kh. Erdenedelger
- N. Radnaakhand
- Khandsuren Byamba
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiologic and preclinical data, and a small randomized trial in Boston, suggest that vitamin D supplementation may improve winter-related atopic dermatitis (AD).
Objective
To determine the effect of vitamin D supplementation on winter-related AD.
Methods
We performed a randomized, double-blind, placebo-controlled trial of Mongolian children with winter-related AD (clinicaltrials.gov identifier: NCT00879424). Baseline eligibility included age 2 to 17 years, AD score 10 to 72 using the Eczema Area and Severity Index (EASI), and winter-related AD (eg, history of AD worsening during the fall-to-winter transition). Subjects were enrolled in Ulaanbaatar during winter and randomly assigned to oral cholecalciferol (1000 IU/day) versus placebo for 1 month. All children and parents received emollient and patient education about AD and basic skin care. The main outcomes were changes in EASI score and in Investigator's Global Assessment.
Results
The 107 enrolled children had a mean age of 9 years (SD 5), and 59% were male. Their median age of AD onset was 3 months (interquartile range 2 months to 1 year) and mean EASI score at baseline 21 (SD 9). One-month follow-up data were available for 104 (97%) children. Compared with placebo, vitamin D supplementation for 1 month produced a clinically and statistically significant improvement in EASI score (adjusted mean change: -6.5 vs -3.3, respectively; P = .04). Moreover, change in Investigator's Global Assessment favored vitamin D over placebo (P = .03). There were no adverse effects in either group.
Conclusion
Vitamin D supplementation improved winter-related AD among Mongolian children, a population likely to have vitamin D deficiency in winter.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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