Caffeine delays autonomic recovery following acute exercise
Bunsawat K, White DW, Kappus RM, Baynard T
European journal of preventive cardiology · 46 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-10-08 · Eur J Prev Cardiol · vol. 22 · número 11 · págs. 1473–1479
- Editorial
- Oxford University Press
- Citado
- 61 citas · más que el 91% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Heart Rate Variability and Autonomic Control · Cardiovascular and exercise physiology
- Palabras clave
- caffeine, autonomic recovery, post-exercise recovery, heart rate variability, QTc interval, sympathetic activity, baroreflex, sudden cardiac death risk, catecholamines, exercise-induced arrhythmia, blood pressure
- MeSH
- heart, autonomic nervous system, humans, caffeine, exercise, cross-over studies, double-blind method, recovery of function, heart rate, baroreflex, time factors, adult, chicago, female, male, arterial pressure, healthy volunteers
4 autores
- Kanokwan Bunsawat🇺🇸 · autor de correspondenciaUniversity of Illinois Chicago
- Daniel Wade White🇺🇸University of Illinois Chicago
- Rebecca M. Kappus🇺🇸University of Illinois Chicago
- Tracy Baynard🇺🇸University of Illinois Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Impaired autonomic recovery of heart rate (HR) following exercise is associated with an increased risk of sudden death. Caffeine, a potent stimulator of catecholamine release, has been shown to augment blood pressure (BP) and sympathetic nerve activity; however, whether caffeine alters autonomic function after a bout of exercise bout remains unclear.
Methods
In a randomized, crossover study, 18 healthy individuals (26 ± 1 years; 23.9 ± 0.8 kg·m(-2)) ingested caffeine (400 mg) or placebo pills, followed by a maximal treadmill test to exhaustion. Autonomic function and ventricular depolarization/repolarization were determined using heart rate variability (HRV) and corrected QT interval (QTc), respectively, at baseline, 5, 15, and 30 minutes post-exercise.
Results
Maximal HR (HRmax) was greater with caffeine (192 ± 2 vs. 190 ± 2 beat·min(-1), p < 0.05). During recovery, HR, mean arterial pressure (MAP), and diastolic blood pressure (DBP) remained elevated with caffeine (p < 0.05). Natural log transformation of low-to-high frequency ratio (LnLF/LnHF) of HRV was increased compared with baseline at all time points in both trials (p < 0.05), with less of an increase during 5 and 15 minutes post-exercise in the caffeine trial (p < 0.05). QTc increased from baseline at all time points in both trials, with greater increases in the caffeine trial (p < 0.05).
Conclusions
Caffeine ingestion disrupts post-exercise autonomic recovery because of increased sympathetic nerve activity. The prolonged sympathetic recovery time could subsequently hinder baroreflex function during recovery and disrupt the stability of autonomic function, potentiating a pro-arrhythmogenic state in young adults.
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