Effects of combined calcium and vitamin D supplementation on insulin secretion, insulin sensitivity and β-cell function in multi-ethnic vitamin D-deficient adults at risk for type 2 diabetes: a pilot randomized, placebo-controlled trial
Gagnon C, Daly RM, Carpentier A, Lu ZX, Shore-Lorenti C, Sikaris K, Jean S, Ebeling PR
PloS one · 101 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Diabetes Australia Research Trust
- Organización sin fines de lucro
- Diabetes Australia
- Universidad u hospital
- University of Melbourne
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-10-09 · PLoS One · vol. 9 · número 10 · pág. e109607
- Editorial
- Public Library of Science
- Citado
- 143 citas · más que el 99% de estudios similares · 9.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Diabetes, Cardiovascular Risks, and Lipoproteins · Bone health and osteoporosis research
- Palabras clave
- vitamin D supplementation, calcium supplementation, vitamin D3, calcium carbonate, vitamin D deficiency, type 2 diabetes risk, prediabetes, insulin sensitivity, insulin secretion, beta-cell function, inflammation, osteocalcin, 25-hydroxyvitamin D, metabolic biomarkers, C-peptide, adiponectin
- MeSH
- humans, diabetes mellitus, type 2, prediabetic state, insulin resistance, vitamin d deficiency, calcium, dietary, cholecalciferol, insulin, c-peptide, blood glucose, tumor necrosis factor-alpha, c-reactive protein, osteocalcin, interleukin-6, pilot projects, dietary supplements, adult, aged, middle aged, female, male, insulin-secreting cells, adiponectin
8 autores
- Claudia Gagnon🇦🇺 · autor de correspondenciaThe University of Melbourne; Western Health; Western Hospital
- Robin M. Daly🇦🇺The University of Melbourne; Western Health; Western Hospital
- André C. Carpentier🇨🇦Université de Sherbrooke
- Zhong Xian Lu🇦🇺Monash University
- Catherine Shore‐Lorenti🇦🇺The University of Melbourne; Western Health; Western Hospital
- Ken A. Sikaris
- Sonia Jean🇨🇦Institut National de Santé Publique du Québec; Université Laval
- Peter Robert Ebeling🇦🇺The University of Melbourne; Western Health; Western Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To examine whether combined vitamin D and calcium supplementation improves insulin sensitivity, insulin secretion, β-cell function, inflammation and metabolic markers.
Design
6-month randomized, placebo-controlled trial.
Participants
Ninety-five adults with serum 25-hydroxyvitamin D [25(OH)D] ≤55 nmol/L at risk of type 2 diabetes (with prediabetes or an AUSDRISK score ≥15) were randomized. Analyses included participants who completed the baseline and final visits (treatment n = 35; placebo n = 45).
Intervention
Daily calcium carbonate (1,200 mg) and cholecalciferol [2,000-6,000 IU to target 25(OH)D >75 nmol/L] or matching placebos for 6 months.
Measurements
Insulin sensitivity (HOMA2%S, Matsuda index), insulin secretion (insulinogenic index, area under the curve (AUC) for C-peptide) and β-cell function (Matsuda index x AUC for C-peptide) derived from a 75 g 2-h OGTT; anthropometry; blood pressure; lipid profile; hs-CRP; TNF-α; IL-6; adiponectin; total and undercarboxylated osteocalcin.
Results
Participants were middle-aged adults (mean age 54 years; 69% Europid) at risk of type 2 diabetes (48% with prediabetes). Compliance was >80% for calcium and vitamin D. Mean serum 25(OH)D concentration increased from 48 to 95 nmol/L in the treatment group (91% achieved >75 nmol/L), but remained unchanged in controls. There were no significant changes in insulin sensitivity, insulin secretion and β-cell function, or in inflammatory and metabolic markers between or within the groups, before or after adjustment for potential confounders including waist circumference and season of recruitment. In a post hoc analysis restricted to participants with prediabetes, a significant beneficial effect of vitamin D and calcium supplementation on insulin sensitivity (HOMA%S and Matsuda) was observed.
Conclusions
Daily vitamin D and calcium supplementation for 6 months may not change OGTT-derived measures of insulin sensitivity, insulin secretion and β-cell function in multi-ethnic adults with low vitamin D status at risk of type 2 diabetes. However, in participants with prediabetes, supplementation with vitamin D and calcium may improve insulin sensitivity.
Trial registration
Australian New Zealand Clinical Trials Registry ACTRN12609000043235.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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