Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome
Asemi Z, Foroozanfard F, Hashemi T, Bahmani F, Jamilian M, Esmaillzadeh A
Clinical nutrition (Edinburgh, Scotland) · 100 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Kashan University of Medical Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 2014-10-04 · Clin Nutr · vol. 34 · número 4 · págs. 586–592
- Editorial
- Elsevier BV
- Citado
- 140 citas · más que el 99% de estudios similares · 12.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ovarian function and disorders · Vitamin D Research Studies · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- polycystic ovary syndrome, vitamin D deficiency, calcium supplementation, vitamin D supplementation, insulin resistance, glucose metabolism, lipid profile, triglycerides, VLDL cholesterol, overweight women, obesity, serum insulin, HOMA-IR, QUICKI, fasting blood glucose, cholesterol levels
- MeSH
- humans, polycystic ovary syndrome, insulin resistance, vitamin d deficiency, obesity, calcium, dietary, insulin, blood glucose, triglycerides, vitamin d, body mass index, fasting, double-blind method, energy intake, dietary supplements, adolescent, adult, female, overweight, carbohydrate metabolism, lipid metabolism, cholesterol, ldl, cholesterol, hdl, waist circumference, young adult
6 autores
- Zatollah Asemi🇮🇷Kashan University of Medical Sciences
- Fatemeh Foroozanfard🇮🇷Kashan University of Medical Sciences
- Teibeh Hashemi🇮🇷Kashan University of Medical Sciences
- Fereshteh Bahmani🇮🇷Kashan University of Medical Sciences
- Mehri Jamilian🇮🇷Arak University of Medical Sciences
- Ahmad Esmaillzadeh🇮🇷Isfahan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Few studies have examined the effects of calcium plus vitamin D supplementation on glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome (PCOS). This study was conducted to determine the effects of calcium plus vitamin D supplementation on glucose metabolism and lipid concentrations among overweight and obese vitamin D deficient women with PCOS.
Methods
This randomized double-blind placebo-controlled clinical trial was conducted among 104 overweight and obese vitamin D deficient women diagnosed with PCOS. Participants were randomly assigned into four groups to receive: 1) 1000 mg/d calcium + vitamin D placebo (n = 26); 2) 50,000 IU/wk vitamin D + calcium placebo (n = 26); 3) 1000 mg calcium/d + 50,000 IU/wk vitamin D (n = 26) and 4) calcium placebo + vitamin D placebo (n = 26) for 8 weeks. Fasting blood samples were taken at baseline and after 8 weeks' intervention to measure glucose metabolism and lipid concentrations.
Results
Calcium-vitamin D co-supplementation resulted in higher levels of serum calcium (P = 0.002) and vitamin D (P < 0.001) compared with other groups. Co-supplementation, compared with other groups, led to decreased serum insulin levels (P = 0.03), homeostasis model of assessment-insulin resistance (HOMA-IR) score (P = 0.04) and a significant rise in quantitative insulin sensitivity check index (QUICKI) (P = 0.001). Furthermore, a significant decrease in serum triglycerides (P = 0.02) and VLDL-cholesterol levels (P = 0.02) was seen following the administration of calcium plus vitamin D supplements compared with the other groups. Co-supplementation with calcium and vitamin D had no significant effects on FPG, total-, LDL-, HDL-, and non-HDL-cholesterol levels.
Conclusions
In conclusion, calcium plus vitamin D supplementation for eight weeks among vitamin D deficient women with PCOS had beneficial effects on serum insulin levels, HOMA-IR, QUICKI, serum triglycerides and VLDL-cholesterol levels, but it did not affect FPG and other lipid profiles. Clinical registration numberwww.irct.ir: IRCT201309275623N10.
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