Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome--a randomized study
Magnusdottir OK, Landberg R, Gunnarsdottir I, Cloetens L, Åkesson B, Rosqvist F, Schwab U, Herzig KH, Hukkanen J, Savolainen MJ, Brader L, Hermansen K, Kolehmainen M, Poutanen K, Uusitupa M, Risérus U, Thorsdottir I
PloS one · 31 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Gobierno
- Strategiske Forskningsråd
- Organización sin fines de lucro
- Foundation for Cardiovascular Research
- Gobierno
- Academy of Finland
- Universidad u hospital
- Kuopion Yliopistollinen Sairaala
- Gobierno
- Vetenskapsrådet
- Gobierno
- NordForsk
- Organización sin fines de lucro
- Sydäntutkimussäätiö
- Gobierno
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Organización sin fines de lucro
- European Society for Clinical Nutrition and Metabolism
- Organización sin fines de lucro
- Diabetesfonden
- Organización sin fines de lucro
- Diabetestutkimussäätiö
- Subvenciones
- NordForsk (070014)); Academy of Finland (070014)
Según 11 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-10-23 · PLoS One · vol. 9 · número 10 · pág. e110827
- Editorial
- Public Library of Science
- Citado
- 54 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food composition and properties · Liver Disease Diagnosis and Treatment · Metabolomics and Mass Spectrometry Studies
- Palabras clave
- Body mass index, Confounding, Medicine, Blood lipids, Population, Cholesterol, Lipid profile, Biomarker, Refined grains, Whole grains, Internal medicine, Animal science, Food science, Biology, Biochemistry
- MeSH
- humans, resorcinols, cholesterol, lipids, body mass index, diet, adult, aged, middle aged, female, male, biomarkers, secale, whole grains, metabolic syndrome
17 autores
- Óla Kallý Magnúsdóttir🇮🇸 · autor de correspondenciaUniversity of Iceland; National University Hospital of Iceland
- Rikard Landberg🇸🇪Karolinska Institutet; Swedish University of Agricultural Sciences
- Ingibjörg Gunnarsdóttir🇮🇸University of Iceland; National University Hospital of Iceland
- Lieselotte Cloetens🇸🇪Lund University
- Björn Åkesson🇸🇪Lund University; Skåne University Hospital
- Fredrik Rosqvist🇸🇪Uppsala University
- Ursula Schwab🇫🇮University of Eastern Finland; Kuopio University Hospital
- Karl‐Heinz Herzig🇫🇮Kuopio University Hospital
- Janne Hukkanen🇫🇮Oulu University Hospital; University of Oulu
- Markku J. Savolainen🇫🇮Oulu University Hospital; University of Oulu
- Lea Brader🇩🇰Aarhus University Hospital
- Kjeld Hermansen🇩🇰Aarhus University Hospital
- Marjukka Kolehmainen🇫🇮University of Eastern Finland; Eastern Finland Laboratory Center; VTT Technical Research Centre of Finland
- Kaisa S Poutanen🇫🇮University of Eastern Finland; Eastern Finland Laboratory Center; VTT Technical Research Centre of Finland
- Matti I.J. Uusitupa🇫🇮University of Eastern Finland; Kuopio University Hospital
- Ulf Risérus🇸🇪Uppsala University
- Inga Þórsdóttir🇮🇸University of Iceland; National University Hospital of Iceland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aim
Few studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to investigate the association between plasma alkylresorcinols (AR), a biomarker for whole grain wheat and rye intake, and blood lipid concentrations in a population with metabolic syndrome. Furthermore, we analyzed the associations between the AR C17:0/C21:0 ratio, a suggested marker of the relative intake of whole grain/bran rye, and blood lipid concentrations.
Methods
Participants were 30-65 years of age, with body mass index (BMI) 27-40 kg/m2 and had metabolic syndrome. Individuals were recruited through six centers in the Nordic countries and randomized either to a healthy Nordic diet (ND, n = 93), rich in whole grain rye and wheat, as well as berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products, or a control diet (n = 65) for 18/24 weeks. Associations between total plasma AR concentration and C17:0/C21:0 homologue ratio and blood lipids were investigated in pooled (ND + control group) regression analyses at 18/24 weeks adjusted for baseline value for the dependent variable, age, BMI and statin use.
Results
When adjusted for confounders, total plasma AR at 18/24 weeks was not significantly associated with blood lipids but the AR ratio C17:0/C21:0 was inversely associated with LDL cholesterol concentrations (B (95% CI): -0.41 (-0.80 to -0.02)), log LDL/HDL cholesterol ratio (-0.20 (-0.37 to -0.03)), log non-HDL cholesterol (-0.20 (-0.37 to -0.03)), log apolipoprotein B (-0.12 (-0.24 to 0.00)) and log triglyceride concentrations (-0.35 (-0.59 to -0.12)).
Discussion
Increased proportion of whole grain rye, reflected by a biomarker, in the diet is associated with favorable blood lipid outcomes, a relationship that should be further investigated.
Trial registration
ClinicalTrials.gov NCT00992641.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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