Effects of pistachio nut supplementation on blood glucose in patients with type 2 diabetes: a randomized crossover trial
Parham M, Heidari S, Khorramirad A, Hozoori M, Hosseinzadeh F, Bakhtyari L, Vafaeimanesh J
The review of diabetic studies : RDS · 63 citas
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-01-01 · Rev Diabet Stud · vol. 11 · número 2 · págs. 190–196
- Citado
- 88 citas · más que el 96% de estudios similares · 4.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Peanut Plant Research Studies · Botany, Ecology, and Taxonomy Studies
- Palabras clave
- Medicine, Glycemic, Randomized controlled trial, Internal medicine, Postprandial, Diabetes mellitus, Type 2 diabetes, Traditional medicine, Endocrinology
- MeSH
- humans, pistacia, nuts, diabetes mellitus, type 2, insulin resistance, blood glucose, c-reactive protein, placebos, body mass index, diet, cross-over studies, double-blind method, blood pressure, postprandial period, adult, middle aged, iran, female, male, glycated hemoglobin
7 autores
- Mahmoud Parham🇮🇷Qom University of Medical Science and Health Services
- Saeide Heidari🇮🇷Qom University of Medical Science and Health Services
- Ashraf Khorramirad🇮🇷Qom University of Medical Science and Health Services
- Mohammad Hozoori🇮🇷Qom University of Medical Science and Health Services
- Fatemeh Mohammad Hosseinzadeh🇮🇷Qom University of Medical Science and Health Services
- Lida Bakhtyari🇮🇷Shahid Beheshti University of Medical Sciences; Qom University of Medical Science and Health Services
- Jamshid Vafaeimanesh🇮🇷 · autor de correspondenciaShahid Beheshti University of Medical Sciences; Qom University of Medical Science and Health Services
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Diabetes is a chronic, potentially debilitating, and often fatal disease. Dietary strategies to reduce postprandial glycemia are important in the prevention and treatment of diabetes. Nuts are rich in mono- and polyunsaturated fatty acids, which may reduce hyperglycemia and improve metabolism.
Objectives
To evaluate the effectiveness of pistachio nut supplementation on glycemic and inflammatory measures in patients with type 2 diabetes.
Methods
In this double-blind, randomized, placebo-controlled, crossover trial, 48 diabetic patients were equally assigned to groups A and B. Patients in group A received a snack of 25 g pistachio nuts twice a day for 12 weeks and group B received a control meal without nuts. After 12 weeks of intervention, the patients had an 8-week washout. Then the groups were displaced, and group B received the same amount of pistachios for 12 weeks.
Results
With respect to the total change in variables over both phases, there was a marked decrease in HbA1c (-0.4%) and fasting blood glucose (FBG) concentrations (-16 mg/dl) in the pistachio group compared with the control group (p ≤ 0.001 for both). There was no overall significant change in BMI, blood pressure, HOMA-IR, and C-reactive protein (CRP) concentrations. Analysis of the two phases separately showed a decrease in FBG by 14 mg/dl and in HbA1c by 0.45% in the treatment group (A) after 12 weeks, while no significant differences were seen in group B (control group). In the second phase, FBG decreased from 151.36 ± 39.22 to 137.28 ± 28.65 mg/dl (-14 mg/dl) and HbA1c decreased from 7.42 ± 0.97 to 7.15 ± 0.68 mg/dl (-0.28%, p = 0.013 and p = 0.033, respectively) in the pistachio group (B). Pistachio consumption reduced systolic blood pressure (p = 0.007), BMI (p = 0.011), and CRP (p = 0.002) in patients from the treatment groups, but not insulin resistance.
Conclusions
Dietary consumption of pistachio nuts as a snack has beneficial effects on glycemic control, blood pressure, obesity, and inflammation markers in diabetic patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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