Influence of pistachios on performance and exercise-induced inflammation, oxidative stress, immune dysfunction, and metabolite shifts in cyclists: a randomized, crossover trial
Nieman DC, Scherr J, Luo B, Meaney MP, Dréau D, Sha W, Dew DA, Henson DA, Pappan KL
PloS one · 52 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-11-19 · PLoS One · vol. 9 · número 11 · pág. e113725
- Editorial
- Public Library of Science
- Citado
- 67 citas · más que el 94% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Exercise and Physiological Responses · Nuts composition and effects · Muscle metabolism and nutrition
- Palabras clave
- Crossover study, Raffinose, Oxidative stress, Chemistry, Metabolite, Time trial, Internal medicine, Ingestion, Endocrinology, Food science, Medicine, Animal science, Sucrose, Biology, Blood pressure, Placebo
- MeSH
- intestinal mucosa, granulocytes, mitochondria, humans, pistacia, inflammation, sucrose, raffinose, f2-isoprostanes, c-reactive protein, exotoxins, cytokines, cross-over studies, phagocytosis, oxidative stress, permeability, bicycling, dietary supplements, adult, middle aged, male, physical exertion, metabolomics, athletes
9 autores
- David Christopher Nieman🇺🇸 · autor de correspondenciaAppalachian State University
- Johannes Scherr🇩🇪TUM Klinikum
- Beibei Luo🇨🇳Second Military Medical University
- Mary Pat Meaney🇺🇸Appalachian State University
- Didier Dréau
- Wei Sha🇺🇸University of North Carolina at Charlotte
- Dustin A. Dew🇺🇸Appalachian State University
- Dru Anne Henson🇺🇸Appalachian State University
- Kirk L. Pappan🇺🇸Metabolon (United States)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Pistachio nut ingestion (3 oz./d, two weeks) was tested for effects on exercise performance and 21-h post-exercise recovery from inflammation, oxidative stress, immune dysfunction, and metabolite shifts.
Methods
Using a randomized, crossover approach, cyclists (N = 19) engaged in two 75-km time trials after 2-weeks pistachio or no pistachio supplementation, with a 2-week washout period. Subjects came to the lab in an overnight fasted state, and ingested water only or 3 oz. pistachios with water before and during exercise. Blood samples were collected 45 min pre-exercise, and immediately post-, 1.5-h post-, and 21-h post-exercise, and analyzed for plasma cytokines, C-reactive protein (CRP), F2-isoprostanes (F2-IsoP), granulocyte phagocytosis (GPHAG) and oxidative burst activity (GOBA), and shifts in metabolites.
Results
Performance time for the 75-km time trial was 4.8% slower under pistachio conditions (2.84 ± 0.11 and 2.71 ± 0.07 h, respectively, P = 0.034). Significant time effects were shown for plasma cytokines, CRP, F2-IsoP, GPHAG, and GOBA, with few group differences. Metabolomics analysis revealed 423 detectable compounds of known identity, with significant interaction effects for 19 metabolites, especially raffinose, (12Z)-9,10-Dihydroxyoctadec-12-enoate (9,10-DiHOME), and sucrose. Dietary intake of raffinose was 2.19 ± 0.15 and 0.35 ± 0.08 mg/d during the pistachio and no pistachio periods, and metabolomics revealed that colon raffinose and sucrose translocated to the circulation during exercise due to increased gut permeability. The post-exercise increase in plasma raffinose correlated significantly with 9,10-DiHOME and other oxidative stress metabolites.
Conclusions
In summary, 2-weeks pistachio nut ingestion was associated with reduced 75-km cycling time trial performance and increased post-exercise plasma levels of raffinose, sucrose, and metabolites related to leukotoxic effects and oxidative stress.
Trial registration
ClinicalTrials.gov NCT01821820.
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