Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults
Casey DP, Treichler DP, Ganger CT, Schneider AC, Ueda K
Journal of applied physiology (Bethesda, Md. : 1985) · 58 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL‐105467)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2014-11-20 · J Appl Physiol (1985) · vol. 118 · número 2 · págs. 178–186
- Editorial
- American Physiological Society
- Citado
- 70 citas · más que el 94% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 68 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Heart Rate Variability and Autonomic Control · Cardiovascular and exercise physiology · High Altitude and Hypoxia
- Palabras clave
- Vasodilation, Internal medicine, Nitric oxide, Medicine, Hypoxia (environmental), Nitrite, Dietary Nitrate, Endocrinology, Forearm, Cardiology, Anesthesia, Nitrate, Chemistry, Oxygen, Surgery
- MeSH
- muscle, skeletal, humans, beta vulgaris, nitrates, plant extracts, phytotherapy, exercise, age factors, aging, vasodilation, dietary supplements, adult, aged, middle aged, female, male, young adult, hypoxia
5 autores
- Darren P. Casey🇺🇸 · autor de correspondenciaUniversity of Iowa
- David P. Treichler🇺🇸University of Iowa
- Charles T. Ganger🇺🇸University of Iowa
- Aaron C. Schneider🇺🇸University of Iowa
- Kenichi Ueda🇺🇸University of Iowa
Resumen
El texto original del estudio, en el idioma en que se publicó.
We have previously demonstrated that aging reduces the compensatory vasodilator response during hypoxic exercise due to blunted nitric oxide (NO) signaling. Recent evidence suggests that NO bioavailability can be augmented by dietary nitrate through the nitrate-nitrite pathway. Thus we tested the hypothesis that acute dietary nitrate supplementation increases the compensatory vasodilator response to hypoxic exercise, particularly in older adults. Thirteen young (25 ± 1 yr) and 12 older (64 ± 2 yr) adults performed rhythmic forearm exercise at 20% of maximum voluntary contraction during normoxia and hypoxia (∼80% O2 saturation); both before (control) and 3 h after beetroot juice (BR) consumption. Forearm vascular conductance (FVC; ml·min(-1)·100 mmHg(-1)) was calculated from forearm blood flow (ml/min) and blood pressure (mmHg). Compensatory vasodilation was defined as the relative increase in FVC due to hypoxic exercise (i.e., % increase compared with respective normoxic exercise trial). Plasma nitrite was determined from venous blood samples obtained before the control trials and each of the exercise trials (normoxia and hypoxia) after BR. Consumption of BR increased plasma nitrite in both young and older adults (P < 0.001). During the control condition, the compensatory vasodilator response to hypoxic exercise was attenuated in older compared with young adults (3.8 ± 1.7% vs. 14.2 ± 1.2%, P < 0.001). Following BR consumption, compensatory vasodilation did not change in young (13.7 ± 3.3%, P = 0.81) adults but was substantially augmented in older adults (11.4 ± 2.1%, P < 0.01). Our data suggest that acute dietary nitrate supplementation increases the compensatory vasodilator response to hypoxic exercise in older but not young adults.
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