Effect of a low-fat diet enriched either with rapeseed oil or sunflower oil on plasma lipoproteins in children and adolescents with familial hypercholesterolaemia. Results of a pilot study
Negele L, Schneider B, Ristl R, Stulnig TM, Willfort-Ehringer A, Helk O, Widhalm K
European journal of clinical nutrition · 22 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-11-26 · Eur J Clin Nutr · vol. 69 · número 3 · págs. 337–343
- Editorial
- Springer Nature
- Citado
- 32 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Fatty Acid Research and Health · Cholesterol and Lipid Metabolism
- Palabras clave
- familial hypercholesterolemia, rapeseed oil, sunflower oil, low-fat diet, monounsaturated fatty acids, polyunsaturated fatty acids, LDL cholesterol, total cholesterol, HDL cholesterol, LDL/HDL ratio, C-reactive protein, cardiovascular risk, children and adolescents, dietary adherence, dietary habits
- MeSH
- humans, helianthus, brassica rapa, cholesterol, dietary fats, unsaturated, fatty acids, monounsaturated, plant oils, c-reactive protein, diet, fat-restricted, pilot projects, double-blind method, feeding behavior, adolescent, child, female, male, hyperlipoproteinemia type ii, cholesterol, ldl, cholesterol, hdl, sunflower oil, rapeseed oil
7 autores
- L Negele🇦🇹Medical University of Vienna
- Barbara Schneider🇦🇹Medical University of Vienna
- Robin Ristl🇦🇹Medical University of Vienna
- Thomas M. Stulnig🇦🇹Medical University of Vienna
- Andrea Willfort‐Ehringer🇦🇹Medical University of Vienna
- Oliver Helk
- Kurt Widhalm🇦🇹 · autor de correspondenciaMedical University of Vienna
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
There is convincing evidence that unsaturated fatty acids exert favourable effects on plasma cholesterol levels. However, it is not clear which type of oil has the most pronounced effect, especially not in paediatric patients. The aim was to compare two low-fat diet regimes enriched with either monounsaturated fatty acids by rapeseed oil (RO) or polyunsaturated fatty acids by sunflower oil (SO) in children affected with familial hypercholesterolaemia (FH).
Subjects/methods
Twenty-one children aged 6-18 years affected with FH were enrolled in this randomized and double-blind pilot trial. The subjects and their families were trained to adhere to a low-fat/low-cholesterol diet. All visible fats were to be replaced by either RO or SO (14-27 g/day) for 13 weeks. Dietary adherence was controlled by repeated 4-day dietary records; plasma lipids, lipoproteins and risk markers were assessed at baseline and post-intervention. Out of 21 subjects, 16 could be followed-up after 6 months.
Results
Both fat-modified diets resulted in significant reduction in total cholesterol concentrations of 9.4% (RO P<0.005 vs SO P<0.05) and low-density lipoprotein (LDL) cholesterol concentrations of 12.7% (P<0.005) for RO and 11.3% (P<0.05) for SO. The reduction of the LDL/high-density lipoprotein (HDL) cholesterol ratio (RO 9% vs SO 3.5%) and high-sensitivity C-reactive protein (RO 16.8% vs SO 1.7%) were not statistically significant, respectively. In most participating families, a change in eating habits could be observed.
Conclusions
A fat-modified diet enriched with RO seems to have very similar effects on cholesterol levels as with SO. However, our study suggests that RO has possibly more favourable effects concerning cardiovascular risk profile. Both diets appear to be feasible and were well accepted among our subjects. Although these results are promising, larger trials will be required to validate our findings.
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