Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients
Berry MJ, Justus NW, Hauser JI, Case AH, Helms CC, Basu S, Rogers Z, Lewis MT, Miller GD
Nitric oxide : biology and chemistry · 96 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Universidad u hospital
- Translational Science Center, Wake Forest University
- Gobierno
- National Institute of Nursing Research
- Gobierno
- NINR NIH HHS
- Universidad u hospital
- Translational Science Center
- Gobierno
- National Institutes of Health Grant
- Subvenciones
- National Institute of Nursing Research (R01 NR011186); National Institute of Nursing Research (NR011186); National Institutes of Health (NR011186)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2014-10-27 · Nitric Oxide · vol. 48 · págs. 22–30
- Editorial
- Elsevier BV
- Citado
- 134 citas · más que el 100% de estudios similares · 34.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Nitric Oxide and Endothelin Effects
- Palabras clave
- dietary nitrate, beetroot juice, chronic obstructive pulmonary disease, exercise capacity, blood pressure, plasma nitrate, plasma nitrite, submaximal exercise, dyspnea, oxygen consumption, heart rate
- MeSH
- humans, beta vulgaris, pulmonary disease, chronic obstructive, dyspnea, nitrates, nitrites, oxygen, treatment outcome, exercise, blood pressure, heart rate, beverages, dietary supplements, aged, middle aged, female, male
9 autores
- Michael J. Berry🇺🇸 · autor de correspondenciaWake Forest University
- Nicholas W. Justus🇺🇸Wake Forest University
- Jordan I. Hauser🇺🇸Wake Forest University
- Ashlee H. Case🇺🇸Wake Forest University
- Christine Carlisle Helms🇺🇸Wake Forest University
- Swati Basu🇺🇸Wake Forest University
- Zachary Rogers🇺🇸Wake Forest University
- Marc T. Lewis🇺🇸Wake Forest University
- Gary D. Miller🇺🇸Wake Forest University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary nitrate (NO3(-)) supplementation via beetroot juice has been shown to increase the exercise capacity of younger and older adults. The purpose of this study was to investigate the effects of acute NO3(-) ingestion on the submaximal constant work rate exercise capacity of COPD patients. Fifteen patients were assigned in a randomized, single-blind, crossover design to receive one of two treatments (beetroot juice then placebo or placebo then beetroot juice). Submaximal constant work rate exercise time at 75% of the patient's maximal work capacity was the primary outcome. Secondary outcomes included plasma NO3(-) and nitrite (NO2(-)) levels, blood pressure, heart rate, oxygen consumption (VO2), dynamic hyperinflation, dyspnea and leg discomfort. Relative to placebo, beetroot ingestion increased plasma NO3(-) by 938% and NO2(-) by 379%. Median (+interquartile range) exercise time was significantly longer (p = 0.031) following the ingestion of beetroot versus placebo (375.0 + 257.0 vs. 346.2 + 148.0 s, respectively). Compared with placebo, beetroot ingestion significantly reduced iso-time (p = 0.001) and end exercise (p = 0.008) diastolic blood pressures by 6.4 and 5.6 mmHg, respectively. Resting systolic blood pressure was significantly reduced (p = 0.019) by 8.2 mmHg for the beetroot versus the placebo trial. No other variables were significantly different between the beetroot and placebo trials. These results indicate that acute dietary NO3(-) supplementation can elevate plasma NO3(-) and NO2(-) concentrations, improve exercise performance, and reduce blood pressure in COPD patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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