Omega-3 fatty acids intake and risks of dementia and Alzheimer's disease: a meta-analysis
Wu S, Ding Y, Wu F, Li R, Hou J, Mao P
Neuroscience and biobehavioral reviews · 109 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-11-21 · Neurosci Biobehav Rev · vol. 48 · págs. 1–9
- Editorial
- Elsevier BV
- Citado
- 155 citas · más que el 80% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Dementia and Cognitive Impairment Research · Nutritional Studies and Diet
- Palabras clave
- omega-3 fatty acids, n-3 long-chain polyunsaturated fatty acids, fish consumption, dementia, Alzheimer's disease, dietary intake, dementia risk, dose-response relationship
- MeSH
- animals, fishes, humans, dementia, alzheimer disease, fatty acids, omega-3, diet, risk
6 autores
- Shunquan Wu🇨🇳302 Military Hospital of China
- Yingying Ding🇨🇳Second Military Medical University
- Fuquan Wu🇨🇳Second Military Medical University; Eastern Hepatobiliary Surgery Hospital
- Ruisheng Li🇨🇳302 Military Hospital of China
- Jun Hou🇨🇳 · autor de correspondencia302 Military Hospital of China
- Panyong Mao🇨🇳 · autor de correspondencia302 Military Hospital of China
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
We systematically reviewed the association of omega-3 fatty acids intake with the incidence of dementia and Alzheimer's disease (AD) in this meta-analysis of prospective cohort studies, as evidence from previous studies suggests inconsistent results.
Methods
We identified relevant studies by searching PubMed, EmBase, and Web of Science databases up to June 2013. Prospective cohort studies reporting on associations of dietary intake of long-chain omega-3 fatty acids or fish with the incidence of dementia and AD were eligible.
Results
Comparing the highest to lowest category of long-chain omega-3 fatty acids intake and fish intake, the pooled relative risks (RRs) for dementia were 0.97 (95% CI 0.85-1.10) and 0.84 (95% CI 0.71-1.01), respectively. Evidence synthesis for AD risk did not show a statistically significant association with long-chain omega-3 fatty acids intake (RR=0.89, 95% CI 0.74-1.08). However, a higher intake of fish was associated with a 36% (95% CI 8-56%) lower risk of AD. Dose-response meta-analysis showed that an increment of 100g per week of fish intake was associated with an 11% lower risk of AD (RR=0.89, 95% CI 0.79-0.99). There was limited evidence of heterogeneity across studies or within subgroups.
Conclusion
A higher intake of fish was associated with a lower risk of AD. However, there was no statistical evidence for similar inverse association between long-chain omega-3 fatty acids intake and risk of dementia or AD, nor was there inverse association between fish intake and risk of dementia.
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