Analysis of vitamin D levels in patients with and without statin-associated myalgia - a systematic review and meta-analysis of 7 studies with 2420 patients
Michalska-Kasiczak M, Sahebkar A, Mikhailidis DP, Rysz J, Muntner P, Toth PP, Jones SR, Rizzo M, Kees Hovingh G, Farnier M, Moriarty PM, Bittner VA, Lip GY, Banach M, Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
International journal of cardiology · 123 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-10-22 · Int J Cardiol · vol. 178 · págs. 111–116
- Editorial
- Elsevier BV
- Citado
- 171 citas · más que el 96% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Lipoproteins and Cardiovascular Health · Pharmacovigilance and Adverse Drug Reactions
- Palabras clave
- vitamin D deficiency, statin adverse effects, serum vitamin D levels, vitamin D supplementation, statin therapy
- MeSH
- humans, vitamin d, hydroxymethylglutaryl-coa reductase inhibitors, myalgia, biomarkers, observational studies as topic
14 autores
- Marta Michalska🇵🇱Medical University of Lodz
- Amirhossein Sahebkar🇮🇷🇦🇺Mashhad University of Medical Sciences; The University of Western Australia; Royal Perth Hospital
- Dimitri P. Mikhailidis🇬🇧The Royal Free Hospital; University College London
- Jacek Rysz🇵🇱Medical University of Lodz
- Paul Muntner🇺🇸University of Alabama at Birmingham
- Peter Paul Toth🇺🇸Johns Hopkins University; Johns Hopkins Medicine; CGH Medical Center
- Steven Richard Jones🇺🇸Johns Hopkins Medicine
- Manfredi Rizzo🇮🇹University of Palermo
- G. Kees Hovingh🇳🇱Amsterdam UMC Location University of Amsterdam
- Michel Farnier
- Patrick M. Moriarty🇺🇸University of Kansas Medical Center
- Vera Bittner🇺🇸University of Alabama at Birmingham; UAB Medicine
- Gregory Y.H. Lip🇬🇧Birmingham City Hospital; University of Birmingham
- Maciej Banach🇵🇱 · autor de correspondenciaMedical University of Lodz
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Vitamin D (vit D) deficiency may be associated with an increased risk of statin-related symptomatic myalgia in statin-treated patients. The aim of this meta-analysis was to substantiate the role of serum vitamin D levels in statin-associated myalgia.
Methods
The search included PUBMED, Cochrane Library, Scopus, and EMBASE from January 1, 1987 to April 1, 2014 to identify studies that investigated the impact of vit D levels in statin-treated subjects with and without myalgia. Two independent reviewers extracted data on study characteristics, methods and outcomes. Quantitative data synthesis was performed using a fixed-effect model.
Results
The electronic search yielded 437 articles; of those 20 were scrutinized as full texts and 13 studies were considered unsuitable. The final analysis included 7 studies with 2420 statin-treated patients divided into subgroups of patients with (n=666 [27.5%]) or without (n=1754) myalgia. Plasma vit D concentrations in the symptomatic and asymptomatic subgroups were 28.4±13.80ng/mL and 34.86±11.63ng/mL, respectively. The combination of data from individual observational studies showed that vit D plasma concentrations were significantly lower in patients with statin-associated myalgia compared with patients not manifesting this side effect (weighted mean difference -9.41ng/mL; 95% confidence interval: -10.17 to -8.64; p<0.00001).
Conclusions
This meta-analysis provides evidence that low vit D levels are associated with myalgia in patients on statin therapy. Randomized controlled trials are necessary to establish whether vitamin D supplementation reduces the risk for statin-associated myalgia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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