Roles of caloric restriction, ketogenic diet and intermittent fasting during initiation, progression and metastasis of cancer in animal models: a systematic review and meta-analysis
Lv M, Zhu X, Wang H, Wang F, Guan W
PloS one · 159 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Animales
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-12-11 · PLoS One · vol. 9 · número 12 · pág. e115147
- Editorial
- Public Library of Science
- Citado
- 208 citas · más que el 82% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 89 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Diet and metabolism studies
- Palabras clave
- caloric restriction, ketogenic diet, intermittent fasting, dietary restriction, cancer prevention, tumor initiation, tumor progression, metastasis, animal models of cancer, tumor incidence
- MeSH
- animals, humans, neoplasms, neoplasm metastasis, disease models, animal, caloric restriction, fasting, pubmed, diet, ketogenic
5 autores
- Mengmeng Lv🇨🇳Jiangsu Cancer Hospital; Nanjing Medical University
- Xingya Zhu🇨🇳Nanjing Medical University; Nanjing University
- Hao Wang🇨🇳Nanjing University
- Feng Wang🇨🇳Nanjing University
- Wenxian Guan🇨🇳 · autor de correspondenciaNanjing University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The role of dietary restriction regimens such as caloric restriction, ketogenic diet and intermittent fasting in development of cancers has been detected via abundant preclinical experiments. However, the conclusions are controversial. We aim to review the relevant animal studies systematically and provide assistance for further clinical studies.
Methods
Literatures on associations between dietary restriction and cancer published in PubMed in recent twenty years were comprehensively searched. Animal model, tumor type, feeding regimen, study length, sample size, major outcome, conclusion, quality assessment score and the interferential step of cancer were extracted from each eligible study. We analyzed the tumor incidence rates from 21 studies about caloric restriction.
Results
Fifty-nine studies were involved in our system review. The involved studies explored roles of dietary restriction during initiation, progression and metastasis of cancer. About 90.9% of the relevant studies showed that caloric restriction plays an anti-cancer role, with the pooled OR (95%CI) of 0.20 (0.12, 0.34) relative to controls. Ketogenic diet was also positively associated with cancer, which was indicated by eight of the nine studies. However, 37.5% of the related studies obtained a negative conclusion that intermittent fasting was not significantly preventive against cancer.
Conclusions
Caloric restriction and ketogenic diet are effective against cancer in animal experiments while the role of intermittent fasting is doubtful and still needs exploration. More clinical experiments are needed and more suitable patterns for humans should be investigated.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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