Olive oil in the prevention and treatment of osteoporosis after artificial menopause
Liu H, Huang H, Li B, Wu D, Wang F, Zheng Xh, Chen Q, Wu B, Fan X
Clinical interventions in aging · 35 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-12-01 · Clin Interv Aging · vol. 9 · pág. 2087
- Editorial
- Dove Medical Press
- Citado
- 43 citas · más que el 70% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Edible Oils Quality and Analysis · Menopause: Health Impacts and Treatments · Fatty Acid Research and Health
- Palabras clave
- Medicine, Menopause, Osteoporosis, Internal medicine, Intensive care medicine
- MeSH
- animals, humans, rats, rats, sprague-dawley, osteoporosis, postmenopausal, nitrates, calcium, phosphorus, malondialdehyde, plant oils, alpha-fetoproteins, carcinoembryonic antigen, anti-inflammatory agents, antigens, tumor-associated, carbohydrate, interleukin-6, estrogens, antioxidants, absorptiometry, photon, bone density, female, olive oil
9 autores
- Huilan Liu🇨🇳Xiamen University
- Huijuan Huang🇨🇳Xiamen University
- Baoheng Li🇨🇳Xiamen University
- Wu Dong🇨🇳Xiamen University
- Fengmei Wang🇨🇳Xiamen University
- Xiaohua Zheng🇨🇳Xiamen University
- Qingxia Chen🇨🇳Xiamen University
- Bifang Wu🇨🇳Xiamen University
- Xiaojie Fan🇨🇳Xiamen University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The goal of this study was to investigate the anti-osteoporosis effect of extra virgin olive oil (EVOO) in vivo, and explore its antioxidant, anti-inflammatory properties in Sprague Dawley rats and its anticancer properties in patients.
Materials and methods
A total of 120 healthy female Sprague Dawley rats aged 6 months were divided into four groups: 1) sham-operated control (Sham group, n=30); 2) ovariectomized (OVX group, n=30); 3) ovariectomized rats supplemented with EVOO (OVX + Olive, n=30); 4) ovariectomized rats supplemented with estrogen (OVX + E2, n=30). EVOO and estrogen were administered by oral gavage at a dose of 1 mL/100 g weight on a daily basis for 12 consecutive weeks. Twelve weeks later blood samples were obtained to detect the levels of calcium, alkaline phosphatase, phosphorus, interleukin-6 (IL-6), malonyldialdehyde (MDA), and nitrate content. Dual energy X-ray absorptiometer measured bone mineral density (BMD) of ovariectomized Sprague Dawley rats that had been fed olive oil for 3 months. Blood samples from patients, who regularly consumed olive oil over a 1 year period were also used to measure carbohydrate antigen 125, carcino-embryonic antigen, α-fetoprotein, and carbohydrate antigen 19-9 levels. BMD of lumbar spine and left femur was also evaluated by dual energy X-ray absorptiometry.
Results
Animal experiments showed that EVOO significantly increased BMD and decreased phosphatase, alkaline phosphatase, IL-6, MDA, and nitrate levels. However, it had no significant effect on the Ca(2+) level. In clinical follow-up, EVOO also improved patient BMD levels on L3, L4, and left femoral neck, and reduced carbohydrate antigen 125, α-fetoprotein, and carcino-embryonic antigen levels. But it had no significant effect on the carbohydrate antigen 19-9 level.
Conclusion
EVOO illustrated significant anti-osteoporosis, antioxidant, anti-inflammatory, and anticancer properties in vivo. However, further studies are required to determine the active component(s) responsible for these effects.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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