Financiado en parte por Almond Board of California
Effect of mastication on lipid bioaccessibility of almonds in a randomized human study and its implications for digestion kinetics, metabolizable energy, and postprandial lipemia
Grundy MM, Grassby T, Mandalari G, Waldron KW, Butterworth PJ, Berry SE, Ellis PR
The American journal of clinical nutrition · 86 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Sin resultado de salud
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Almond Board of California
- Universidad u hospital
- King’s College London
- Universidad u hospital
- King's College London
- Universidad u hospital
- Institute of Food Research
- Universidad u hospital
- Università degli Studi di Messina
- Gobierno
- Directorate for Biological Sciences
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Subvenciones
- Institute of Food Research (BB/H004866/1); Biotechnology and Biological Sciences Research Council (BBS/E/F/00044476); Biotechnology and Biological Sciences Research Council (BB/H004866/1); Biotechnology and Biological Sciences Research Council (H004866/H004866/1); Biotechnology and Biological Sciences Research Council (1060666); Biotechnology and Biological Sciences Research Council (BB/H004874/1); Biotechnology and Biological Sciences Research Council (BB/H004866/1); Biotechnology and Biological Sciences Research Council (BB/H004874/1)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2014-11-13 · Am J Clin Nutr · vol. 101 · número 1 · págs. 25–33
- Editorial
- Elsevier BV
- Citado
- 136 citas · más que el 98% de estudios similares · 6.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Nutrition and Health in Aging · Body Composition Measurement Techniques
- Palabras clave
- Postprandial, Mastication, Digestion (alchemy), Chemistry, Food science, Kinetics, Chromatography, Medicine, Dentistry, Internal medicine
- MeSH
- humans, prunus, nuts, dietary fats, cross-over studies, single-blind method, energy metabolism, digestion, intestinal absorption, mastication, postprandial period, particle size, models, biological, food handling, adult, female, male, hyperlipidemias, young adult, functional food
7 autores
- Myriam M.-L. Grundy🇮🇹🇬🇧University of Messina; King's College London; Norwich Research Park; Quadram Institute
- Terri Grassby🇮🇹🇬🇧University of Messina; King's College London; Norwich Research Park; Quadram Institute
- Giuseppina Mandalari🇮🇹🇬🇧University of Messina; King's College London; Norwich Research Park; Quadram Institute
- Keith W. Waldron🇮🇹🇬🇧University of Messina; King's College London; Norwich Research Park; Quadram Institute
- Peter Butterworth🇮🇹🇬🇧University of Messina; King's College London; Norwich Research Park; Quadram Institute
- Sarah E. Berry🇮🇹🇬🇧University of Messina; King's College London; Norwich Research Park; Quadram Institute
- P. R. Ellis🇮🇹🇬🇧 · autor de correspondenciaUniversity of Messina; King's College London; Norwich Research Park; Quadram Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The particle size and structure of masticated almonds have a significant impact on nutrient release (bioaccessibility) and digestion kinetics.
Objectives
The goals of this study were to quantify the effects of mastication on the bioaccessibility of intracellular lipid of almond tissue and examine microstructural characteristics of masticated almonds.
Design
In a randomized, subject-blind, crossover trial, 17 healthy subjects chewed natural almonds (NAs) or roasted almonds (RAs) in 4 separate mastication sessions. Particle size distributions (PSDs) of the expectorated boluses were measured by using mechanical sieving and laser diffraction (primary outcome). The microstructure of masticated almonds, including the structural integrity of the cell walls (i.e., dietary fiber), was examined with microscopy. Lipid bioaccessibility was predicted by using a theoretical model, based on almond particle size and cell dimensions, and then compared with empirically derived release data.
Results
Intersubject variations (n = 15; 2 subjects withdrew) in PSDs of both NA and RA samples were small (e.g., laser diffraction; CV: 12% and 9%, respectively). Significant differences in PSDs were found between these 2 almond forms (P 500 μm) in masticated almonds. Microstructural examination of the almonds indicated that most intracellular lipid remained undisturbed in intact cells after mastication. No adverse events were recorded.
Conclusions
Following mastication, most of the almond cells remained intact with lipid encapsulated by cell walls. Thus, most of the lipid in masticated almonds is not immediately bioaccessible and remains unavailable for early stages of digestion. The lipid encapsulation mechanism provides a convincing explanation for why almonds have a low metabolizable energy content and an attenuated impact on postprandial lipemia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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