Financiado en parte por Sovena Company
Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study
Silva S, Bronze MR, Figueira ME, Siwy J, Mischak H, Combet E, Mullen W
The American journal of clinical nutrition · 43 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Universidade de Lisboa
- Empresa
- Sovena Company
- Universidad u hospital
- University of Lisbon
- Subvenciones
- Universidade de Lisboa (12228)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2014-11-20 · Am J Clin Nutr · vol. 101 · número 1 · págs. 44–54
- Editorial
- Elsevier BV
- Citado
- 56 citas · más que el 92% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Edible Oils Quality and Analysis · Nutritional Studies and Diet · Fatty Acid Research and Health
- Palabras clave
- olive oil supplementation, olive oil phenolic compounds, coronary artery disease, chronic kidney disease, diabetes mellitus, cardiovascular disease prevention, LDL oxidation, antioxidant capacity, LDL cholesterol, triglycerides, healthy adults
- MeSH
- humans, diabetic nephropathies, proteinuria, diabetes mellitus, type 1, diabetes mellitus, type 2, phenols, plant oils, risk factors, case-control studies, cohort studies, double-blind method, diet, mediterranean, adolescent, adult, scotland, female, male, renal insufficiency, chronic, coronary artery disease, young adult, functional food, biomarkers, olive oil
7 autores
- Sandra Regina Augusta da Silva🇵🇹🇩🇪🇬🇧University of Lisbon; Mosaiques Diagnostics and Therapeutics (Germany); Instituto de Biologia Experimental e Tecnológica; University of Glasgow
- Maria Rosário Bronze🇵🇹🇩🇪🇬🇧University of Lisbon; Mosaiques Diagnostics and Therapeutics (Germany); Instituto de Biologia Experimental e Tecnológica; University of Glasgow
- Maria Eduardo Figueira🇵🇹🇩🇪🇬🇧University of Lisbon; Mosaiques Diagnostics and Therapeutics (Germany); Instituto de Biologia Experimental e Tecnológica; University of Glasgow
- Justyna Siwy🇵🇹🇩🇪🇬🇧University of Lisbon; Mosaiques Diagnostics and Therapeutics (Germany); Instituto de Biologia Experimental e Tecnológica; University of Glasgow
- Harald Mischak🇵🇹🇩🇪🇬🇧University of Lisbon; Mosaiques Diagnostics and Therapeutics (Germany); Instituto de Biologia Experimental e Tecnológica; University of Glasgow
- Emilie Combet🇵🇹🇩🇪🇬🇧 · autor de correspondenciaUniversity of Lisbon; Mosaiques Diagnostics and Therapeutics (Germany); Instituto de Biologia Experimental e Tecnológica; University of Glasgow
- William Mullen🇵🇹🇩🇪🇬🇧University of Lisbon; Mosaiques Diagnostics and Therapeutics (Germany); Instituto de Biologia Experimental e Tecnológica; University of Glasgow
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Olive oil (OO) consumption is associated with cardiovascular disease prevention because of both its oleic acid and phenolic contents. The capacity of OO phenolics to protect against low-density lipoprotein (LDL) oxidation is the basis for a health claim by the European Food Safety Authority. Proteomic biomarkers enable an early, presymptomatic diagnosis of disease, which makes them important and effective, but understudied, tools for primary prevention.
Objective
We evaluated the impact of supplementation with OO, either low or high in phenolics, on urinary proteomic biomarkers of coronary artery disease (CAD), chronic kidney disease (CKD), and diabetes.
Design
Self-reported healthy participants (n = 69) were randomly allocated (stratified block random assignment) according to age and body mass index to supplementation with a daily 20-mL dose of OO either low or high in phenolics (18 compared with 286 mg caffeic acid equivalents per kg, respectively) for 6 wk. Urinary proteomic biomarkers were measured at baseline and 3 and 6 wk alongside blood lipids, the antioxidant capacity, and glycation markers.
Results
The consumption of both OOs improved the proteomic CAD score at endpoint compared with baseline (mean improvement: -0.3 for low-phenolic OO and -0.2 for high-phenolic OO; P < 0.01) but not CKD or diabetes proteomic biomarkers. However, there was no difference between groups for changes in proteomic biomarkers or any secondary outcomes including plasma triacylglycerols, oxidized LDL, and LDL cholesterol.
Conclusion
In comparison with low-phenolic OO, supplementation for 6 wk with high-phenolic OO does not lead to an improvement in cardiovascular health markers in a healthy cohort.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.