High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans
Jones PJ, MacKay DS, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Kris-Etherton PM, West SG, Liu X, Fleming JA, Hantgan RR, Rudel LL
Atherosclerosis · 38 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL1-TR000127); National Heart, Lung, and Blood Institute (HL 49373); National Heart, Lung, and Blood Institute (P01HL049373)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2014-12-09 · Atherosclerosis · vol. 238 · número 2 · págs. 231–238
- Editorial
- Elsevier BV
- Citado
- 56 citas · más que el 93% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health
- Palabras clave
- linoleic acid, docosahexaenoic acid, dietary fatty acid composition, Mediterranean diet
- MeSH
- humans, cardiovascular diseases, cholesterol esters, proteoglycans, dietary fats, corn oil, docosahexaenoic acids, safflower oil, linoleic acid, fatty acids, monounsaturated, oleic acid, risk factors, cross-over studies, double-blind method, risk reduction behavior, diet, mediterranean, time factors, adult, middle aged, canada, united states, female, male, cholesterol, ldl, rapeseed oil
14 autores
- Peter J.H. Jones🇨🇦University of Manitoba
- Dylan MacKay🇨🇦University of Manitoba
- Vijitha K. Senanayake🇨🇦University of Manitoba
- Shuaihua Pu🇨🇦University of Manitoba
- David J.A. Jenkins🇨🇦St. Michael's Hospital; University of Toronto
- Philip W. Connelly🇨🇦St. Michael's Hospital; University of Toronto
- Benoı̂t Lamarche🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF)
- Patrick Couture🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF)
- Penny M. Kris‐Etherton🇺🇸Pennsylvania State University
- Sheila G. West🇺🇸Pennsylvania State University
- Xiaoran Liu🇺🇸Pennsylvania State University
- Jennifer A Fleming🇺🇸Pennsylvania State University
- Roy R. Hantgan🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Lawrence L. Rudel🇺🇸Wake Forest University Health Sciences; Wake Forest University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Oleic acid consumption is considered cardio-protective according to studies conducted examining effects of the Mediterranean diet. However, animal models have shown that oleic acid consumption increases LDL particle cholesteryl oleate content which is associated with increased LDL-proteoglycan binding and atherosclerosis. The objective was to examine effects of varying oleic, linoleic and docosahexaenoic acid consumption on human LDL-proteoglycan binding in a non-random subset of the Canola Oil Multi-center Intervention Trial (COMIT) participants. COMIT employed a randomized, double-blind, five-period, cross-over trial design. Three of the treatment oil diets: 1) a blend of corn/safflower oil (25:75); 2) high oleic canola oil; and 3) DHA-enriched high oleic canola oil were selected for analysis of LDL-proteoglycan binding in 50 participants exhibiting good compliance. LDL particles were isolated from frozen plasma by gel filtration chromatography and LDL cholesteryl esters quantified by mass-spectrometry. LDL-proteoglycan binding was assessed using surface plasmon resonance. LDL particle cholesterol ester fatty acid composition was sensitive to the treatment fatty acid compositions, with the main fatty acids in the treatments increasing in the LDL cholesterol esters. The corn/safflower oil and high-oleic canola oil diets lowered LDL-proteoglycan binding relative to their baseline values (p = 0.0005 and p = 0.0012, respectively). At endpoint, high-oleic canola oil feeding resulted in lower LDL-proteoglycan binding than corn/safflower oil (p = 0.0243) and DHA-enriched high oleic canola oil (p = 0.0249), although high-oleic canola oil had the lowest binding at baseline (p = 0.0344). Our findings suggest that high-oleic canola oil consumption in humans increases cholesteryl oleate percentage in LDL, but in a manner not associated with a rise in LDL-proteoglycan binding.
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