Acute dietary nitrate supplementation does not augment submaximal forearm exercise hyperemia in healthy young men
Kim JK, Moore DJ, Maurer DG, Kim-Shapiro DB, Basu S, Flanagan MP, Skulas-Ray AC, Kris-Etherton P, Proctor DN
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 37 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Universidad u hospital
- Social Science Research Institute, Pennsylvania State University
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL058091); National Center for Advancing Translational Sciences (UL1-TR000127); National Heart, Lung, and Blood Institute (R37HL058091); National Heart, Lung, and Blood Institute (R29 HL058091); National Heart, Lung, and Blood Institute (R01 HL058091)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2014-10-15 · Appl Physiol Nutr Metab · vol. 40 · número 2 · págs. 122–128
- Editorial
- NRC Research Press
- Citado
- 46 citas · más que el 86% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Heart Rate Variability and Autonomic Control · Cardiovascular Health and Disease Prevention · Cardiovascular and exercise physiology
- Palabras clave
- Brachial artery, Arterial stiffness, Medicine, Pulse wave velocity, Crossover study, Nitrate, Placebo, Vasodilation, Reactive hyperemia, Internal medicine, Cardiology, Radial artery, Forearm, Blood pressure, Endocrinology, Artery, Surgery, Chemistry, Pathology
- MeSH
- forearm, humans, beta vulgaris, plant roots, hyperemia, nitrates, plant extracts, hand strength, exercise, cross-over studies, double-blind method, reference values, beverages, dietary supplements, adult, male, young adult
9 autores
- Jin‐Kwang Kim🇺🇸Pennsylvania State University
- David J. Moore🇺🇸Pennsylvania State University
- David G. Maurer🇺🇸Pennsylvania State University
- Daniel B. Kim‐Shapiro🇺🇸Wake Forest University
- Swati Basu🇺🇸Wake Forest University
- Michael Patrick Flanagan🇺🇸Penn State Milton S. Hershey Medical Center
- Ann C. Skulas‐Ray🇺🇸Pennsylvania State University
- Penny M. Kris‐Etherton🇺🇸Pennsylvania State University
- David N. Proctor🇺🇸Pennsylvania State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Despite the popularity of dietary nitrate supplementation and the growing evidence base of its potential ergogenic and vascular health benefits, there is no direct information about its effects on exercising limb blood flow in humans. We hypothesized that acute dietary nitrate supplementation from beetroot juice would augment the increases in forearm blood flow, as well as the progressive dilation of the brachial artery, during graded handgrip exercise in healthy young men. In a randomized, double-blind, placebo-controlled crossover study, 12 young (22 ± 2 years) healthy men consumed a beetroot juice (140 mL Beet-It Sport, James White Juice Company) that provided 12.9 mmol (0.8 g) of nitrate or placebo (nitrate-depleted Beet-It Sport) on 2 study visits. At 3 h postconsumption, brachial artery diameter, flow, and blood velocity were measured (Doppler ultrasound) at rest and during 6 exercise intensities. Nitrate supplementation raised plasma nitrate (19.5-fold) and nitrite (1.6-fold) concentrations, and lowered resting arterial pulse wave velocity (PWV) versus placebo (all p < 0.05), indicating absorption, conversion, and a biological effect of this supplement. The supplement-associated lowering of PWV was also negatively correlated with plasma nitrite (r = -0.72, p = 0.0127). Despite these systemic effects, nitrate supplementation had no effect on brachial artery diameter, flow, or shear rates at rest (all p ≥ 0.28) or during any exercise workload (all p ≥ 0.18). These findings suggest that acute dietary nitrate supplementation favorably modifies arterial PWV, but does not augment blood flow or brachial artery vasodilation during nonfatiguing forearm exercise in healthy young men.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.