Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism
Wegman MP, Guo MH, Bennion DM, Shankar MN, Chrzanowski SM, Goldberg LA, Xu J, Williams TA, Lu X, Hsu SI, Anton SD, Leeuwenburgh C, Brantly ML
Rejuvenation research · 89 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Florida
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIA NIH HHS
- Gobierno
- NCATS NIH HHS
- Gobierno
- NICHD NIH HHS
- Subvenciones
- University of Florida (UL1TR000064); National Heart, Lung, and Blood Institute (T32-HL-083810); National Center for Advancing Translational Sciences (UL1-TR001427); University of Florida (P30 AG028740); National Institutes of Health (UL1TR000064); National Center for Advancing Translational Sciences (TL1TR000066); University of Florida (TL1 TR000066); National Institutes of Health (TL1 TR000066); National Institutes of Health (TR000064); National Institute on Aging (P30AG028740); Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD043730)
Según 10 financiadores declarados.
Publicación
- Publicado
- 2014-12-29 · Rejuvenation Res · vol. 18 · número 2 · págs. 162–172
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 135 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Dietary Effects on Health · Genetics, Aging, and Longevity in Model Organisms · Sirtuins and Resveratrol in Medicine
- Palabras clave
- intermittent fasting, oxidative stress, aging, SIRT3, sirtuins, antioxidant supplementation, vitamin C, vitamin E, insulin, gene expression, caloric restriction, dietary adherence
- MeSH
- humans, antioxidants, caloric restriction, fasting, cross-over studies, double-blind method, feeding behavior, patient compliance, age factors, gene expression regulation, energy metabolism, oxidative stress, aging, time factors, dietary supplements, adult, patient satisfaction, florida, female, male, young adult, sirtuin 3, healthy volunteers
13 autores
- Martin P Wegman🇺🇸University of Florida Health; University of Florida
- Michael H. Guo🇺🇸Harvard University; University of Florida Health; University of Florida
- Douglas M. Bennion🇺🇸University of Florida Health; University of Florida
- Meena N. Shankar🇺🇸University of Florida
- Stephen Mark Chrzanowski🇺🇸University of Florida Health; University of Florida
- Leslie A. Goldberg🇺🇸University of Florida Health; University of Florida
- Jinze Xu🇺🇸University of Florida Health; University of Florida
- Tiffany A. Williams🇺🇸University of Florida Health; University of Florida
- Xiaomin Lu🇺🇸University of Florida
- Stephen I‐Hong Hsu
- Stephen Douglas Anton🇺🇸University of Florida Health; University of Florida
- Christiaan Leeuwenburgh🇺🇸University of Florida Health; University of Florida
- Mark Brantly🇺🇸 · autor de correspondenciaUniversity of Florida Health; University of Florida
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caloric restriction has consistently been shown to extend life span and ameliorate aging-related diseases. These effects may be due to diet-induced reactive oxygen species acting to up-regulate sirtuins and related protective pathways, which research suggests may be partially inhibited by dietary anti-oxidant supplementation. Because caloric restriction is not sustainable long term for most humans, we investigated an alternative dietary approach, intermittent fasting (IF), which is proposed to act on similar biological pathways. We hypothesized that a modified IF diet, where participants maintain overall energy balance by alternating between days of fasting (25% of normal caloric intake) and feasting (175% of normal), would increase expression of genes associated with aging and reduce oxidative stress and that these effects would be suppressed by anti-oxidant supplementation. To assess the tolerability of the diet and to explore effects on biological mechanisms related to aging and metabolism, we recruited a cohort of 24 healthy individuals in a double-crossover, double-blinded, randomized clinical trial. Study participants underwent two 3-week treatment periods-IF and IF with anti-oxidant (vitamins C and E) supplementation. We found strict adherence to study-provided diets and that participants found the diet tolerable, with no adverse clinical findings or weight change. We detected a marginal increase (2.7%) in SIRT3 expression due to the IF diet, but no change in expression of other genes or oxidative stress markers analyzed. We also found that IF decreased plasma insulin levels (1.01 μU/mL). Although our study suggests that the IF dieting paradigm is acceptable in healthy individuals, additional research is needed to further assess the potential benefits and risks.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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