A red meat-derived glycan promotes inflammation and cancer progression
Samraj AN, Pearce OM, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM, Varki A
Proceedings of the National Academy of Sciences of the United States of America · 297 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Science Foundation
- Organización sin fines de lucro
- Ellison Medical Foundation
- Organización sin fines de lucro
- Cancer Research Institute
- Universidad u hospital
- Harvard University
- Universidad u hospital
- University of Cambridge
- Gobierno
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCI NIH HHS
- Gobierno
- HHS | NIH | National Cancer Institute
- Subvenciones
- National Cancer Institute (R01 CA 38701); National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK 069263); National Cancer Institute (R01 CA038701); National Institutes of Health (P51‐OD011132); National Institutes of Health (R01 CA38701)
Según 13 financiadores declarados.
Publicación
- Publicado
- 2014-12-29 · Proc Natl Acad Sci U S A · vol. 112 · número 2 · págs. 542–547
- Editorial
- National Academy of Sciences
- Citado
- 408 citas · más que el 100% de estudios similares · 45.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 68 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Milk Quality and Mastitis in Dairy Cows · melanin and skin pigmentation · Glycosylation and Glycoproteins Research
- Palabras clave
- Inflammation, Red meat, Sialic acid, Cancer, Biology, Immunology, Medicine, Internal medicine, Food science, Biochemistry
- MeSH
- animals, mice, congenic, mice, inbred c57bl, mice, knockout, humans, mice, liver neoplasms, experimental, disease progression, inflammation, neuraminic acids, n-acetylneuraminic acid, mixed function oxygenases, antibodies, blocking, risk factors, food analysis, meat, male
12 autores
- Annie N. Samraj🇺🇸University of California San Diego
- Oliver M.T. Pearce🇺🇸University of California San Diego
- Heinz Philipp Laubli🇺🇸University of California San Diego
- Alyssa N. Crittenden🇺🇸University of California San Diego
- Anne K. Bergfeld🇺🇸University of California San Diego
- Kalyan Banda🇺🇸University of California San Diego
- Christopher Gregg🇺🇸University of California San Diego
- Andrea E. Bingman🇺🇸University of California San Diego
- Patrick Secrest🇺🇸University of California San Diego
- Sandra L. Diaz🇺🇸University of California San Diego
- Nissi M. Varki🇺🇸University of California San Diego
- Ajit P Varki🇺🇸University of California San Diego
Resumen
El texto original del estudio, en el idioma en que se publicó.
A well known, epidemiologically reproducible risk factor for human carcinomas is the long-term consumption of "red meat" of mammalian origin. Although multiple theories have attempted to explain this human-specific association, none have been conclusively proven. We used an improved method to survey common foods for free and glycosidically bound forms of the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc), showing that it is highly and selectively enriched in red meat. The bound form of Neu5Gc is bioavailable, undergoing metabolic incorporation into human tissues, despite being a foreign antigen. Interactions of this antigen with circulating anti-Neu5Gc antibodies could potentially incite inflammation. Indeed, when human-like Neu5Gc-deficient mice were fed bioavailable Neu5Gc and challenged with anti-Neu5Gc antibodies, they developed evidence of systemic inflammation. Such mice are already prone to develop occasional tumors of the liver, an organ that can incorporate dietary Neu5Gc. Neu5Gc-deficient mice immunized against Neu5Gc and fed bioavailable Neu5Gc developed a much higher incidence of hepatocellular carcinomas, with evidence of Neu5Gc accumulation. Taken together, our data provide an unusual mechanistic explanation for the epidemiological association between red meat consumption and carcinoma risk. This mechanism might also contribute to other chronic inflammatory processes epidemiologically associated with red meat consumption.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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