Delayed Anaphylaxis to Red Meat Associated With Specific IgE Antibodies to Galactose
Wen L, Zhou J, Yin J, Sun JL, Sun Y, Wu K, Katial R
Allergy, asthma & immunology research · 10 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Reporte de caso (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Emory University
- Gobierno
- Foundation of National Epidemiology Study of Asthma and Allergies in China, sector fund of Ministry of Health of China
Según 2 financiadores declarados.
Publicación
- Publicado
- 2014-12-19 · Allergy Asthma Immunol Res · vol. 7 · número 1 · pág. 92
- Citado
- 15 citas · más que el 69% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 9 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Food Allergy and Anaphylaxis Research · Allergic Rhinitis and Sensitization · Contact Dermatitis and Allergies
- Palabras clave
- Immunoglobulin E, Anaphylaxis, Tick, Saliva, Immunology, Antibody, Biology, Primate, Medicine, Allergy, Virology, Biochemistry, Ecology
7 autores
- Liping Wen🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Junxiong Zhou🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Jia Yin🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Jin‐Lu Sun🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Yi Eve Sun🇧🇾🇨🇳Institute of Microbiology; Beijing Institute of Microbiology and Epidemiology
- Kai Wu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Rohit K. Katial🇺🇸National Jewish Health; University of Colorado Denver
Resumen
El texto original del estudio, en el idioma en que se publicó.
A novel delayed anaphylactic reaction to red meat, associated with tick bites and IgE antibodies against galactose-α-1, 3-galactose (α-gal), was reported in 2009 in the US, Australia and Europe. In this case, serum specific IgE to galactose-α-1, 3-galactose (>100 kU/L) and IgE to multiple non-primate mammalian proteins were positive. However, the pathogenesis of this disease remains unclear. We report the first case in Asia of delayed anaphylactic reaction to red meat, which was induced by bites from the hard tick, Hematophagous ixodidae. We confirmed the increased concentration of IgE reactive epitopes in non-primate mammalian organs, which may be rich in α-gal proteins in lymphatic and endothelial tissues. All confirmed ticks associated with this disorder in the literature and in our case belonged to the hard tick family. We hypothesize that hard tick saliva is enriched with blood-type substances, such as oligosaccharides, from the non-primate mammal victim's blood after days to weeks of blood sucking, which sensitizes humans through the injection route while blood sucking.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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