Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles
Varady KA, Dam VT, Klempel MC, Horne M, Cruz R, Kroeger CM, Santosa S
Scientific reports · 37 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Concordia University
- Universidad u hospital
- University of Illinois at Urbana-Champaign
- Gobierno
- Natural Sciences and Engineering Research Council of Canada
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-01-05 · Sci Rep · vol. 5 · número 1 · pág. 7561
- Editorial
- Nature Portfolio
- Citado
- 58 citas · más que el 90% de estudios similares · 2.8× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-SA
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Diet, Metabolism, and Disease
- Palabras clave
- Triglyceride, Waist, Endocrinology, Weight loss, Internal medicine, Context (archaeology), Fatty acid, Composition (language), Chemistry, Low fat diet, Animal science, Cholesterol, Obesity, Medicine, Biology, Biochemistry
- MeSH
- humans, body weight, cholesterol, lipids, dietary fats, fatty acids, nonesterified, triglycerides, body mass index, fasting, body composition, adult, aged, middle aged, female, cholesterol, ldl, waist circumference
7 autores
- Krista A Varady🇺🇸University of Illinois Urbana-Champaign; University of Illinois Chicago
- Vi T. Dam🇺🇸🇨🇦Concordia University; Concordia University; Concordia University
- Monica C Klempel🇺🇸🇨🇦Concordia University; Concordia University
- Matthew J. Horne🇺🇸🇨🇦Concordia University; Concordia University; Concordia University
- Rani Cruz🇺🇸🇨🇦Concordia University; Concordia University; Concordia University
- Cynthia M. Kroeger🇺🇸University of Illinois Urbana-Champaign; University of Illinois Chicago
- Sylvia Santosa🇺🇸🇨🇦Concordia University; Concordia University; Concordia University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Cardiovascular disease risk is associated with excess body weight and elevated plasma free fatty acid (FFA) concentrations. This study examines how an alternate-day fasting (ADF) diet high (HF) or low (LF) in fat affects plasma FFA profiles in the context of weight loss, and changes in body composition and lipid profiles. After a 2-week weight maintenance period, 29 women (BMI 30-39.9 kg/m(2)) 25-65 years old were randomized to an 8-week ADF-HF (45% fat) diet or an ADF-LF (25% fat) diet with 25% energy intake on fast days and ad libitum intake on feed days. Body weight, BMI and waist circumference were assessed weekly and body composition was measured using dual x-ray absorptiometry (DXA). Total and individual FFA and plasma lipid concentrations were measured before and after weight loss. Body weight, BMI, fat mass, total cholesterol, LDL-C and triglyceride concentrations decreased (P < 0.05) in both groups. Total FFA concentrations also decreased (P < 0.001). In the ADF-LF group, decreases were found in several more FFAs than in the ADF-HF group. In the ADF-HF group, FFA concentrations were positively correlated with waist circumference. Depending on the macronutrient composition of a diet, weight loss with an ADF diet decreases FFA concentrations through potentially different mechanisms.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-SA).
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