Effect of an Olive Oil-Based Lipid Emulsion Compared With a Soybean Oil-Based Lipid Emulsion on Liver Chemistry and Bile Acid Composition in Preterm Infants Receiving Parenteral Nutrition: A Double-Blind, Randomized Trial
Wang Y, Zhou KJ, Tang QY, Hong L, Feng Y, Lu LN, Wang WP, Cai W
JPEN. Journal of parenteral and enteral nutrition · 8 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81100631)
Según 1 financiador declarado.
Publicación
- Publicado
- 2015-01-05 · JPEN J Parenter Enteral Nutr · vol. 40 · número 6 · págs. 842–850
- Editorial
- Wiley
- Citado
- 14 citas · más que el 83% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Infant Nutrition and Health · Neonatal Health and Biochemistry
- Palabras clave
- parenteral nutrition, preterm infants, direct bilirubin, bile acid composition, lipid emulsion composition
- MeSH
- liver, humans, cholestasis, liver diseases, bile acids and salts, soybean oil, fat emulsions, intravenous, parenteral nutrition, double-blind method, infant, newborn, infant, premature, female, male, olive oil
8 autores
- Ying Wang🇨🇳Shanghai Jiao Tong University; XinHua Hospital; Shanghai Institute of Nutrition and Health
- Kejun Zhou🇨🇳Shanghai Institute of Nutrition and Health
- Qingya Tang🇨🇳Shanghai Jiao Tong University; XinHua Hospital; Shanghai Institute of Nutrition and Health
- Li Hong🇨🇳Shanghai Jiao Tong University; Shanghai Children's Medical Center
- Yi Feng🇨🇳Shanghai Jiao Tong University; Shanghai Children's Medical Center
- Lina Lu🇨🇳Shanghai Jiao Tong University; XinHua Hospital
- Weiping Wang🇨🇳Shanghai Jiao Tong University; XinHua Hospital
- Wei Cai🇨🇳 · autor de correspondenciaShanghai Jiao Tong University; XinHua Hospital; Shanghai Institute of Nutrition and Health
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The pathogenesis of parenteral nutrition (PN)-associated liver dysfunction is multifactorial. Lipid emulsions may be one of the putative mechanisms. Our aim was to comparatively assess the effect of parenteral olive oil- and soybean oil-based lipid emulsions on liver chemistry and bile acid composition in preterm infants.
Methods
We performed a double-blind, randomized clinical study in which 103 preterm infants were randomly assigned to PN using either soybean oil-based lipid emulsion (SO; n = 51) or olive oil (OO)-based lipid emulsion (OO; n = 52). The primary end point was liver chemistry. The secondary end point was the plasma bile acid composition.
Results
One hundred infants completed this study. In the SO group, the serum direct bilirubin was significantly higher after PN for 7 days compared with the OO group. Bile acids increased over time in both treatment groups. However, specific differences in the change in bile acid composition over time were noted between groups.
Conclusions
Differences in direct bilirubin and bile acid composition were observed over time between the 2 groups. Considering the long-term use of lipid emulsions in higher risk babies, these findings might be useful for understanding the pathogenesis of PN-associated liver dysfunction.
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