Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial
Rita Cardoso B, Apolinário D, da Silva Bandeira V, Busse AL, Magaldi RM, Jacob-Filho W, Cozzolino SM
European journal of nutrition · 84 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-01-07 · Eur J Nutr · vol. 55 · número 1 · págs. 107–116
- Editorial
- Springer Science+Business Media
- Citado
- 143 citas · más que el 99% de estudios similares · 10.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 76 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Selenium in Biological Systems · Dementia and Cognitive Impairment Research · Organoselenium and organotellurium chemistry
- Palabras clave
- Bertholletia excelsa, selenium supplementation, selenium status, mild cognitive impairment, older adults, cognitive function, oxidative stress, antioxidant defense, erythrocyte glutathione peroxidase, malondialdehyde, verbal fluency, constructional praxis, dietary intervention
- MeSH
- humans, bertholletia, nuts, selenium, malondialdehyde, glutathione peroxidase, triglycerides, treatment outcome, pilot projects, cognition, oxidative stress, nutritional status, aged, aged, 80 and over, female, male, cholesterol, ldl, cholesterol, hdl, cognitive dysfunction
7 autores
- Bárbara Rita Cardoso🇧🇷 · autor de correspondenciaUniversidade de São Paulo
- Daniel Apolinário🇧🇷Universidade de São Paulo
- Verônica da Silva Bandeira🇧🇷Universidade de São Paulo
- Alexandre Leopold Busse🇧🇷Universidade de São Paulo
- Regina Miksian Magaldi🇧🇷Universidade de São Paulo
- Wilson Jacob Filho🇧🇷Universidade de São Paulo
- Sílvia Maria Franciscato Cozzolino🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Oxidative stress is closely related to cognitive impairment, and the antioxidant system may be a potential therapeutic target to preserve cognitive function in older adults. Selenium plays an important antioxidant role through selenoproteins. This controlled trial aimed to investigate the antioxidant and cognitive effects of the consumption of Brazil nuts, the best selenium food source.
Methods
We enrolled 31 older adults with mild cognitive impairment (MCI) who were randomly assigned to ingestion of Brazil nuts or to the control group. Participants of the treatment group consumed one Brazil nut daily (estimated 288.75 µg/day) for 6 months. Blood selenium concentrations, erythrocyte glutathione peroxidase (GPx) activity, oxygen radical absorbance capacity, and malondialdehyde were evaluated. Cognitive functions were assessed with the CERAD neuropsychological battery.
Results
Eleven participants of the treated group and nine of the control group completed the trial. The mean age of the participants was 77.7 (±5.3) years, 70 % of whom were female. We observed increased selenium levels after the intervention, whereas the control group presented no change. Among the parameters related to the antioxidant system, only erythrocyte GPx activity change was significantly different between the groups (p = 0.006). After 6 months, improvements in verbal fluency (p = 0.007) and constructional praxis (p = 0.031) were significantly greater on the supplemented group when compared with the control group.
Conclusion
Our results suggest that the intake of Brazil nut restores selenium deficiency and provides preliminary evidence that Brazil nut consumption can have positive effects on some cognitive functions of older adults with MCI.
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