Financiado en parte por Omron Healthcare
Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial
Johnson SA, Figueroa A, Navaei N, Wong A, Kalfon R, Ormsbee LT, Feresin RG, Elam ML, Hooshmand S, Payton ME, Arjmandi BH
Journal of the Academy of Nutrition and Dietetics · 168 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Omron Healthcare
Según 1 financiador declarado.
Publicación
- Publicado
- 2015-01-08 · J Acad Nutr Diet · vol. 115 · número 3 · págs. 369–377
- Editorial
- Elsevier BV
- Citado
- 248 citas · más que el 99% de estudios similares · 16.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Phytochemicals and Antioxidant Activities · Blood Pressure and Hypertension Studies
- Palabras clave
- hypertension, postmenopausal women, arterial stiffness, blood pressure, pulse wave velocity, nitric oxide, C-reactive protein, superoxide dismutase, cardiovascular risk, menopause, oxidative stress, inflammation, vascular function, dietary intervention, stage 1 hypertension, prehypertension
- MeSH
- humans, fruit, hypertension, nitric oxide, superoxide dismutase, c-reactive protein, double-blind method, blood pressure, aged, middle aged, florida, female, ankle brachial index, vascular stiffness, pulse wave analysis, blueberry plants
11 autores
- Sarah A. Johnson🇺🇸Florida State University
- Arturo Figueroa
- Negin Navaei🇺🇸Florida State University
- Alexei Wong🇺🇸🇵🇷Florida State University; University of Puerto Rico-Mayaguez
- Roy Kalfon🇺🇸🇮🇱Florida State University; Technion – Israel Institute of Technology
- Lauren T. Ormsbee🇺🇸Florida State University
- Rafaela G. Feresin🇺🇸Florida State University
- Marcus L. Elam🇺🇸Florida State University
- Shirin Hooshmand🇺🇸San Diego State University
- Mark E. Payton🇺🇸Oklahoma State University
- Bahram Herman Arjmandi🇺🇸 · autor de correspondenciaFlorida State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Postmenopausal women have a high prevalence of hypertension and often develop arterial stiffness thereby increasing cardiovascular disease risk. Although antihypertensive drug therapies exist, increasing numbers of people prefer natural therapies. In vivo studies and a limited number of clinical studies have demonstrated the antihypertensive and vascular-protective effects of blueberries.
Objective
To examine the effects of daily blueberry consumption for 8 weeks on blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension.
Design
This was an 8-week, randomized, double-blind, placebo-controlled clinical trial.
Participants/setting
Forty-eight postmenopausal women with pre- and stage 1-hypertension recruited from the greater Tallahassee, FL, area participated.
Intervention
Participants were randomly assigned to receive either 22 g freeze-dried blueberry powder or 22 g control powder.
Main outcome measures
Resting brachial systolic and diastolic blood pressures were evaluated and arterial stiffness was assessed using carotid-femoral pulse wave velocity and brachial-ankle pulse wave velocity. C-reactive protein, nitric oxide, and superoxide dismutase were measured at baseline, 4 weeks, and 8 weeks.
Statistical analyses performed
Statistical analysis was performed using a split plot model of repeated measures analysis of variance.
Results
After 8 weeks, systolic blood pressure and diastolic blood pressure (131±17 mm Hg [P<0.05] and 75±9 mm Hg [P<0.01], respectively) and brachial-ankle pulse wave velocity (1,401±122 cm/second; P<0.01) were significantly lower than baseline levels (138±14 mm Hg, 80±7 mm Hg, and 1,498±179 cm/second, respectively), with significant (P<0.05) group×time interactions in the blueberry powder group, whereas there were no changes in the group receiving the control powder. Nitric oxide levels were greater (15.35±11.16 μmol/L; P<0.01) in the blueberry powder group at 8 weeks compared with baseline values (9.11±7.95 μmol/L), whereas there were no changes in the control group.
Conclusions
Daily blueberry consumption may reduce blood pressure and arterial stiffness, which may be due, in part, to increased nitric oxide production.
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