Late outcome of a randomized study on oral magnesium for premature complexes
De Falco CN, Darrieux FC, Grupi C, Sacilotto L, Pisani CF, Lara S, Ramires JA, Sosa E, Wu TC, Hachul D, Scanavacca M
Arquivos brasileiros de cardiologia · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-01-01 · Arq Bras Cardiol · vol. 103 · número 6 · págs. 468–75
- Editorial
- Sociedade Brasileira de Cardiologia (SBC)
- Citado
- 3 citas · más que el 9% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY
- Áreas de investigación
- Cardiac electrophysiology and arrhythmias · Magnesium in Health and Disease · Cardiac Arrhythmias and Treatments
- Palabras clave
- ventricular arrhythmias, supraventricular arrhythmias, arrhythmia frequency, symptom improvement, long-term follow-up
- MeSH
- humans, ventricular premature complexes, recurrence, pyrrolidonecarboxylic acid, electrocardiography, ambulatory, treatment outcome, analysis of variance, double-blind method, placebo effect, time factors
11 autores
- Cristina Nádja M. Lima De Falco🇧🇷Instituto do Coração - HCFMUSP
- Francisco Darrieux🇧🇷Instituto do Coração - HCFMUSP
- César Grupi🇧🇷Instituto do Coração - HCFMUSP
- Luciana Sacilotto🇧🇷Instituto do Coração - HCFMUSP
- Cristiano Faria Pisani🇧🇷Instituto do Coração - HCFMUSP
- Sissy Lara🇧🇷Instituto do Coração - HCFMUSP
- José Antônio Franchini Ramires🇧🇷Instituto do Coração - HCFMUSP
- Eduardo Sosa🇧🇷Instituto do Coração - HCFMUSP
- Tan Chen Wu🇧🇷Instituto do Coração - HCFMUSP
- Denise Tessariol HACHUL🇧🇷Instituto do Coração - HCFMUSP
- Maurício Scanavacca🇧🇷Instituto do Coração - HCFMUSP
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Ventricular and supraventricular premature complexes (PC) are frequent and usually symptomatic. According to a previous study, magnesium pidolate (MgP) administration to symptomatic patients can improve the PC density and symptoms.
Objective
To assess the late follow-up of that clinical intervention in patients treated with MgP or placebo.
Methods
In the first phase of the study, 90 symptomatic and consecutive patients with PC were randomized (double-blind) to receive either MgP or placebo for 30 days. Monthly follow-up visits were conducted for 15 months to assess symptoms and control electrolytes. 24-hour Holter was performed twice, regardless of symptoms, or whenever symptoms were present. In the second phase of the study, relapsing patients, who had received MgP or placebo (crossing-over) in the first phase, were treated with MgP according to the same protocol.
Results
Of the 45 patients initially treated with MgP, 17 (37.8%) relapsed during the 15-month follow-up, and the relapse time varied. Relapsing patients treated again had a statistically significant reduction in the PC density of 138.25/hour (p < 0.001). The crossing-over patients reduced it by 247/hour (p < 0.001). Patients who did not relapse, had a low PC frequency (3 PC/hour). Retreated patients had a 76.5% improvement in symptom, and crossing-over patients, 71.4%.
Conclusion
Some patients on MgP had relapse of symptoms and PC, indicating that MgP is neither a definitive nor a curative treatment for late follow-up. However, improvement in the PC frequency and symptoms was observed in the second phase of treatment, similar to the response in the first phase of treatment.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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