The effect of dietary nitrate supplementation on the oxygen cost of cycling, walking performance and resting blood pressure in individuals with chronic obstructive pulmonary disease: A double blind placebo controlled, randomised control trial
Shepherd AI, Wilkerson DP, Dobson L, Kelly J, Winyard PG, Jones AM, Benjamin N, Shore AC, Gilchrist M
Nitric oxide : biology and chemistry · 61 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Torbay Medical Research Fund
- Gobierno
- National Institute for Health and Care Research
- Universidad u hospital
- NIHR Exeter Clinical Research Facility
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Institute for Health and Care Research (CL-2011-23-001)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2015-01-14 · Nitric Oxide · vol. 48 · págs. 31–37
- Editorial
- Elsevier BV
- Citado
- 88 citas · más que el 100% de estudios similares · 23.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Cardiovascular and exercise physiology · Chronic Obstructive Pulmonary Disease (COPD) Research · Nitric Oxide and Endothelin Effects
- Palabras clave
- nitrate supplementation, chronic obstructive pulmonary disease, beetroot juice, oxygen cost of exercise, exercise intolerance, 6-minute walk test, resting blood pressure, cycling, walking performance
- MeSH
- humans, beta vulgaris, pulmonary disease, chronic obstructive, nitrates, oxygen, pulmonary gas exchange, exercise, walking, double-blind method, blood pressure, dietary supplements, adult, aged, middle aged
9 autores
- Anthony I. Shepherd🇬🇧University of Exeter; Royal Devon and Exeter Hospital; NIHR Exeter Clinical Research Facility
- Daryl P. Wilkerson🇬🇧University of Exeter
- Lee Dobson🇬🇧Torbay Hospital
- JAMES A. KELLY🇬🇧University of Exeter
- Paul Graham Winyard🇬🇧University of Exeter; Royal Devon and Exeter Hospital; NIHR Exeter Clinical Research Facility
- ANDREW MARK JONES🇬🇧University of Exeter
- Nigel Benjamin🇬🇧University of Exeter; Royal Devon and Exeter Hospital; Torbay Hospital; NIHR Exeter Clinical Research Facility
- Angela C. Shore🇬🇧University of Exeter; Royal Devon and Exeter Hospital; NIHR Exeter Clinical Research Facility
- Mark Gilchrist🇬🇧 · autor de correspondenciaUniversity of Exeter; Royal Devon & Exeter NHS Foundation Trust; Royal Devon and Exeter Hospital; NIHR Exeter Clinical Research Facility
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Chronic obstructive pulmonary disease (COPD) results in exercise intolerance. Dietary nitrate supplementation has been shown to lower blood pressure (BP), reduce the oxygen cost of exercise, and enhance exercise tolerance in healthy volunteers. This study assessed the effects of dietary nitrate on the oxygen cost of cycling, walking performance and BP in individuals with mild-moderate COPD.
Methods
Thirteen patients with mild-moderate COPD were recruited. Participants consumed 70 ml of either nitrate-rich (6.77 mmol nitrate; beetroot juice) or nitrate-depleted beetroot juice (0.002 mmol nitrate; placebo) twice a day for 2.5 days, with the final supplement ~3 hours before testing. BP was measured before completing two bouts of moderate-intensity cycling, where pulmonary gas exchange was measured throughout. The six-minute walk test (6 MWT) was completed 30 minutes subsequent to the second cycling bout.
Results
Plasma nitrate concentration was significantly elevated following beetroot juice vs. placebo (placebo; 48 ± 86 vs. beetroot juice; 215 ± 84 µM, P = 0.002). No significant differences were observed between placebo vs. beetroot juice for oxygen cost of exercise (933 ± 323 vs. 939 ± 302 ml: min(-1); P = 0.88), distance covered in the 6 MWT (456 ± 86 vs. 449 ± 79 m; P = 0.37), systolic BP (123 ± 14 vs. 123 ± 14 mmHg; P = 0.91), or diastolic BP (77 ± 9 vs. 79 ± 9 mmHg; P = 0.27).
Conclusion
Despite a large rise in plasma nitrate concentration, two days of nitrate supplementation did not reduce the oxygen cost of moderate intensity cycling, increase distance covered in the 6 MWT, or lower BP.
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