Clinical and molecular evidence of the consumption of broccoli, glucoraphanin and sulforaphane in humans
Conzatti A, Fróes FC, Schweigert Perry ID, Souza CG
Nutricion hospitalaria · 26 citas
Cómo se estudió
- Diseño
- Revisión sistemática (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Hospital de Clínicas de Porto Alegre
Según 1 financiador declarado.
Publicación
- Publicado
- 2014-11-30 · Nutr Hosp · vol. 31 · número 2 · págs. 559–69
- Editorial
- National Institutes of Health
- Citado
- 41 citas · más que el 72% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Advanced Glycation End Products research · Cynara cardunculus studies
- Palabras clave
- Glucoraphanin, Sulforaphane, Consumption (sociology), Chemistry, Food science, Brassica, Biology, Botany, Biochemistry, Glucosinolate
- MeSH
- humans, brassica, neoplasms, myocardial infarction, oximes, imidoesters, isothiocyanates, sulfoxides, glucosinolates, anticarcinogenic agents, diet
4 autores
- Adriana Conzatti🇧🇷Universidade Federal do Rio Grande do Sul
- Fernanda Telles Fróes🇧🇷Universidade Federal do Rio Grande do Sul
- Ingrid Dalira Schweigert Perry
- Carolina Guerini de Souza🇧🇷Universidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Sulforaphane (SFN) is an isothiocyanate derived from glucoraphanin (GRA), which is found in great amounts especially in broccoli. Its consumption has been reported to be associated with a lower risk of myocardial infarction and cancer development. Additionally, its effects have been studied in neurodegenerative diseases, diabetes, and atherosclerosis, most of the times using animal models and cell cultures.
Objectives
Given the promising results of SFN, this review aimed to investigate evidence documented in human intervention studies with broccoli, GRA and SFN.
Methods
A search was performed on PubMed and Virtual Health Library databases by two independent researchers using the descriptors "broccoli" or "glucoraphanin" or "sulforaphane", which should appear on the study's title or abstract. This review included randomized clinical trials performed in humans that were published in English and Portuguese from 2003 to 2013 and that considered clinical and molecular parameters of cell damage as outcomes of interest.
Results
Seventeen studies were selected, and the predominant type of intervention was broccoli sprouts. More consistent results were obtained for the clinical parameters blood glucose and lipid profile and for molecular parameters of oxidative stress, indicating that there was an improvement in these parameters after intervention. Less solid evidence was found with regard to decreased inflammation, Helicobacter pylori colonization, and protection against cancer.
Conclusion
Although being relevant, the evidence for the use of broccoli, GRA and SFN in humans are limited; thus, further intervention studies are needed to evaluate outcomes more consistently and reach better grounded conclusions.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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