Antiproliferative and antioxidant properties of anthocyanin rich extracts from blueberry and blackcurrant juice
Diaconeasa Z, Leopold L, Rugină D, Ayvaz H, Socaciu C
International journal of molecular sciences · 99 citas
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Sin resultado de salud
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Autoritatea Natională pentru Cercetare Stiintifică
- Gobierno
- Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii
- Gobierno
- This paper was published under the frame of European Social Fund, Human Resources Development Operational Programme 2007-2013, project no. POSDRU/159/1.5/S/132765 and by a UEFISCDI grant, project number PN-II-RU-PD-2012-3-0283
- Universidad u hospital
- We are also grateful to Dr. Manuela Banciu for providing the B16-F10 murine melanoma cell line and to Chiricuta Cancer Institute, Cluj-Napoca for providing HeLa and A2780 human cancer cell lines
- Subvenciones
- Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii (PN-II-RU-PD-2012-3-0283)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-01-22 · Int J Mol Sci · vol. 16 · número 2 · págs. 2352–2365
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 215 citas · más que el 99% de estudios similares · 10.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 70 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Botanical Research and Applications · Natural Antidiabetic Agents Studies
- Palabras clave
- Anthocyanin, DPPH, Chemistry, Food science, Antioxidant, HeLa, Cyanidin, Flavonoid, Polyphenol, MTT assay, Vaccinium, Delphinidin, ABTS, Traditional medicine, Biochemistry, Botany, Biology, Cell growth, In vitro, Medicine
- MeSH
- cell line, tumor, hela cells, ht29 cells, animals, humans, mice, anthocyanins, plant extracts, antineoplastic agents, phytogenic, antioxidants, chromatography, high pressure liquid, spectrometry, mass, electrospray ionization, cell proliferation, cell survival, beverages, solid phase extraction, blueberry plants
5 autores
- Zorița Maria Diaconeasa🇷🇴University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
- Loredana Florina LEOPOLD🇷🇴University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
- Dumitriţa Ruginǎ🇷🇴University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
- Hüseyin Ayvaz🇹🇷Çanakkale Onsekiz Mart Üniversitesi
- Carmen Socaciu🇷🇴University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
Resumen
El texto original del estudio, en el idioma en que se publicó.
The present study was aimed at evaluating the antiproliferative potential of anthocyanin-rich fractions (ARFs) obtained from two commercially available juices (blueberry and blackcurrant juices) on three tumor cell lines; B16F10 (murine melanoma), A2780 (ovarian cancer) and HeLa (cervical cancer). Individual anthocyanin determination, identification and quantification were done using HPLC-MS. Antioxidant activity of the juices was determined through different mechanism methods such as DPPH and ORAC. For biological testing, the juices were purified through C18 cartridges in order to obtain fractions rich in anthocyanins. The major anthocyanins identified were glycosylated cyanidin derivatives. The antiproliferative activity of the fractions was tested using the MTT assay. The antiproliferative potential of ARF was found to be associated with those bioactive molecules, anthocyanins due to their antioxidant potential. The results obtained indicated that both blueberry and blackcurrants are rich sources of antioxidants including anthocyanins and therefore these fruits are highly recommended for daily consumption to prevent numerous degenerative diseases.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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