Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation
Turner CE, Byblow WD, Gant N
The Journal of neuroscience : the official journal of the Society for Neuroscience · 92 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-01-28 · J Neurosci · vol. 35 · número 4 · págs. 1773–1780
- Editorial
- Society for Neuroscience
- Citado
- 161 citas · más que el 96% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-SA
- Áreas de investigación
- Muscle metabolism and nutrition · Genetic Neurodegenerative Diseases · Advanced MRI Techniques and Applications
- Palabras clave
- Creatine, Neuroprotection, Creatine Monohydrate, Phosphocreatine, Hypoxia (environmental), Medicine, Placebo, Neuropsychology, Internal medicine, Anesthesia, Neuroscience, Endocrinology, Psychology, Oxygen, Cognition, Chemistry, Energy metabolism, Pathology
- MeSH
- motor cortex, ulnar nerve, humans, creatine, aspartic acid, neuroprotective agents, cognition disorders, neuropsychological tests, evoked potentials, motor, blood pressure, heart rate, neural conduction, dietary supplements, adult, middle aged, female, male, transcranial magnetic stimulation, young adult, hypoxia
3 autores
- Clare E. Turner
- Winston D. Byblow🇳🇿University of Auckland; Brain Research New Zealand
- Nicholas Gant
Resumen
El texto original del estudio, en el idioma en que se publicó.
Impairment or interruption of oxygen supply compromises brain function and plays a role in neurological and neurodegenerative conditions. Creatine is a naturally occurring compound involved in the buffering, transport, and regulation of cellular energy, with the potential to replenish cellular adenosine triphosphate without oxygen. Creatine is also neuroprotective in vitro against anoxic/hypoxic damage. Dietary creatine supplementation has been associated with improved symptoms in neurological disorders defined by impaired neural energy provision. Here we investigate, for the first time in humans, the utility of creatine as a dietary supplement to protect against energetic insult. The aim of this study was to assess the influence of oral creatine supplementation on the neurophysiological and neuropsychological function of healthy young adults during acute oxygen deprivation. Fifteen healthy adults were supplemented with creatine and placebo treatments for 7 d, which increased brain creatine on average by 9.2%. A hypoxic gas mixture (10% oxygen) was administered for 90 min, causing global oxygen deficit and impairing a range of neuropsychological processes. Hypoxia-induced decrements in cognitive performance, specifically attentional capacity, were restored when participants were creatine supplemented, and corticomotor excitability increased. A neuromodulatory effect of creatine via increased energy availability is presumed to be a contributing factor of the restoration, perhaps by supporting the maintenance of appropriate neuronal membrane potentials. Dietary creatine monohydrate supplementation augments neural creatine, increases corticomotor excitability, and prevents the decline in attention that occurs during severe oxygen deficit. This is the first demonstration of creatine's utility as a neuroprotective supplement when cellular energy provision is compromised.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-SA).
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