Financiado en parte por Nutricia Research, Nutricia Advanced Medical Nutrition
A high whey protein-, leucine-, and vitamin D-enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial
Verreijen AM, Verlaan S, Engberink MF, Swinkels S, de Vogel-van den Bosch J, Weijs PJ
The American journal of clinical nutrition · 183 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Nutricia Research
- Empresa
- Nutricia Advanced Medical Nutrition
Según 2 financiadores declarados.
Publicación
- Publicado
- 2014-11-26 · Am J Clin Nutr · vol. 101 · número 2 · págs. 279–286
- Editorial
- Elsevier BV
- Citado
- 235 citas · más que el 99% de estudios similares · 10.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutrition and Health in Aging · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Palabras clave
- whey protein supplements, leucine, vitamin D, sarcopenia, muscle mass preservation, intentional weight loss, obesity, older adults, appendicular skeletal muscle mass, grip strength, physical performance, resistance training, hypocaloric diet, body composition, protein intake, fat loss, sarcopenic obesity
- MeSH
- muscle, skeletal, humans, obesity, body weight, weight loss, vitamin d, leucine, dietary proteins, milk proteins, body mass index, hand strength, treatment outcome, diet, reducing, double-blind method, motor activity, body composition, energy intake, dietary supplements, aged, aged, 80 and over, middle aged, female, male, muscle strength, resistance training, sarcopenia, whey proteins
6 autores
- A.M. Verreijen🇳🇱 · autor de correspondenciaNutricia Research (Netherlands); Amsterdam University of Applied Sciences
- Sjors Verlaan🇳🇱Nutricia Research (Netherlands); Amsterdam University of Applied Sciences
- Mariëlle F. Engberink🇳🇱Nutricia Research (Netherlands); Amsterdam University of Applied Sciences
- Sophie H. N. Willemsen‐Swinkels🇳🇱Nutricia Research (Netherlands); Amsterdam University of Applied Sciences
- Johan de Vogel‐van den Bosch🇳🇱Nutricia Research (Netherlands); Amsterdam University of Applied Sciences
- Peter J.M. Weijs🇳🇱Nutricia Research (Netherlands); Amsterdam University of Applied Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intentional weight loss in obese older adults is a risk factor for muscle loss and sarcopenia.
Objective
The objective was to examine the effect of a high whey protein-, leucine-, and vitamin D-enriched supplement on muscle mass preservation during intentional weight loss in obese older adults.
Design
We included 80 obese older adults in a double-blind randomized controlled trial. During a 13-wk weight loss program, all subjects followed a hypocaloric diet (-600 kcal/d) and performed resistance training 3×/wk. Subjects were randomly allocated to a high whey protein-, leucine-, and vitamin D-enriched supplement including a mix of other macro- and micronutrients (150 kcal, 21 g protein; 10×/wk, intervention group) or an isocaloric control. The primary outcome was change in appendicular muscle mass. The secondary outcomes were body composition, handgrip strength, and physical performance. Data were analyzed by using ANCOVA and mixed linear models with sex and baseline value as covariates.
Results
At baseline, mean ± SD age was 63 ± 5.6 y, and body mass index (in kg/m(2)) was 33 ± 4.4. During the trial, protein intake was 1.11 ± 0.28 g · kg body weight(-1) · d(-1) in the intervention group compared with 0.85 ± 0.24 g · kg body weight(-1) · d(-1) in the control group (P < 0.001). Both intervention and control groups decreased in body weight (-3.4 ± 3.6 kg and -2.8 ± 2.8 kg; both P < 0.001) and fat mass (-3.2 ± 3.1 kg and -2.5 ± 2.4 kg; both P < 0.001), with no differences between groups. The 13-wk change in appendicular muscle mass, however, was different in the intervention and control groups [+0.4 ± 1.2 kg and -0.5 ± 2.1 kg, respectively; β = 0.95 kg (95% CI: 0.09, 1.81); P = 0.03]. Muscle strength and function improved over time without significant differences between groups.
Conclusion
A high whey protein-, leucine-, and vitamin D-enriched supplement compared with isocaloric control preserves appendicular muscle mass in obese older adults during a hypocaloric diet and resistance exercise program and might therefore reduce the risk of sarcopenia. This trial was registered at the Dutch Trial Register (http://www.trialregister.nl) as NTR2751.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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