Supplementation of vitamin D in pregnancy and its correlation with feto-maternal outcome
Sablok A, Batra A, Thariani K, Batra A, Bharti R, Aggarwal AR, Kabi BC, Chellani H
Clinical endocrinology · 141 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-02-14 · Clin Endocrinol (Oxf) · vol. 83 · número 4 · págs. 536–541
- Editorial
- Wiley
- Citado
- 233 citas · más que el 100% de estudios similares · 15.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Vitamin K Research Studies · Neonatal Health and Biochemistry
- Palabras clave
- vitamin D supplementation, vitamin D deficiency, pregnancy, vitamin D3, 25-hydroxyvitamin D, preterm labour, preeclampsia, gestational diabetes mellitus, low birth weight, Apgar score, cord blood vitamin D, neonatal outcomes, maternal complications
- MeSH
- humans, pregnancy complications, vitamin d deficiency, birth weight, vitamin d, body mass index, pregnancy, dietary supplements, female
8 autores
- Aanchal Sablok🇮🇳 · autor de correspondenciaSafdarjang Hospital; Vardhman Mahavir Medical College & Safdarjung Hospital
- Aruna Batra🇮🇳Safdarjang Hospital; Vardhman Mahavir Medical College & Safdarjung Hospital
- Karishma Thariani🇮🇳Safdarjang Hospital; Vardhman Mahavir Medical College & Safdarjung Hospital
- Achla Batra🇮🇳Safdarjang Hospital; Vardhman Mahavir Medical College & Safdarjung Hospital
- Rekha Bharti🇮🇳Safdarjang Hospital; Vardhman Mahavir Medical College & Safdarjung Hospital
- Abha Rani Aggarwal🇮🇳National Institute of Medical Statistics; All India Institute of Medical Sciences
- B C Kabi🇮🇳Safdarjang Hospital; Vardhman Mahavir Medical College & Safdarjung Hospital
- Harish Kumar Chellani🇮🇳Safdarjang Hospital; Vardhman Mahavir Medical College & Safdarjung Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Vitamin D deficiency is widely prevalent throughout the world. Pregnant women, neonates and infants form most vulnerable groups for vitamin D deficiency.
Objective
(1) To find prevalence of vitamin D deficiency in pregnant women. (2) To evaluate the effect of supplementation with cholecalciferol in improving vitamin D levels in pregnant women and evaluate its correlation with feto-maternal outcome.
Design
Randomized control trial from years 2010 to 2012.
Setting
Tertiary care centre, Delhi, India.
Participants
One-hundred and eighty pregnant women. Study population divided randomly into two groups: group A: nonintervention (60 women) and group B: intervention (120 women).
Intervention
The intervention group received supplementation of vitamin D in dosages depending upon 25(OH)-D levels.
Main outcome measures
Risk of maternal complications such as preterm labour, pre-eclampsia and gestational diabetes associated with vitamin D deficiency and risk of low birthweight and poor Apgar score in infants of mothers with vitamin D deficiency.
Results
Adjusted serum 25(OH)-D concentration was lower in group A as compared to group B (mean 46·11 ± 74·21 nmol/l vs 80 ± 51·53 nmol/l). Forty-four percent patients in group A and 20·3% patients in group B developed preterm labour/pre-eclampsia/gestational diabetes. Newborns of mothers in group A had lower cord blood levels of 25(OH)-D levels as compared to group B (mean 43·11 ± 81·32 nmol/l vs 56·8 ± 47·52 nmol/l). They also had lower birthweight of mean 2·4 ± 0·38 kg as compared to group B 2·6 ± 0·33 kg.
Conclusions
Vitamin D supplementation reduces risk of maternal comorbidities and helps improve neonatal outcomes.
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