Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer
Rosendahl AH, Perks CM, Zeng L, Markkula A, Simonsson M, Rose C, Ingvar C, Holly JM, Jernström H
Clinical cancer research : an official journal of the American Association for Cancer Research · 111 citas
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Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-02-18 · Clin Cancer Res · vol. 21 · número 8 · págs. 1877–1887
- Editorial
- American Association for Cancer Research
- Citado
- 149 citas · más que el 99% de estudios similares · 11.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Cancer Risks and Factors · Tea Polyphenols and Effects
- Palabras clave
- Estrogen receptor, Breast cancer, Caffeine, Caffeic acid, Tamoxifen, Endocrinology, Internal medicine, Medicine, Cancer, Population, Cancer research, Chemistry, Biochemistry
- MeSH
- cell line, tumor, humans, coffea, breast neoplasms, neoplasm metastasis, neoplasm recurrence, local, caffeic acids, caffeine, receptor, igf type 1, receptors, estrogen, tumor burden, risk factors, cell cycle, cell proliferation, cell survival, adult, aged, aged, 80 and over, middle aged, female, young adult, neoplasm grading, biomarkers, tumor
9 autores
- Ann H. Rosendahl🇸🇪 · autor de correspondenciaSkåne University Hospital
- Claire M. Perks🇬🇧Southmead Hospital
- Li Zeng🇬🇧Southmead Hospital
- Andrea Markkula🇸🇪Skåne University Hospital
- Maria Simonsson🇸🇪Skåne University Hospital
- Carsten Rose🇸🇪Medicon Village
- Christian Ingvar🇸🇪Skåne University Hospital
- Jeff M.P. Holly🇬🇧Southmead Hospital
- Helena Jernström🇸🇪Skåne University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Epidemiologic studies indicate that dietary factors, such as coffee, may influence breast cancer and modulate hormone receptor status. The purpose of this translational study was to investigate how coffee may affect breast cancer growth in relation to estrogen receptor-α (ER) status.
Experimental design
The influence of coffee consumption on patient and tumor characteristics and disease-free survival was assessed in a population-based cohort of 1,090 patients with invasive primary breast cancer in Sweden. Cellular and molecular effects by the coffee constituents caffeine and caffeic acid were evaluated in ER(+) (MCF-7) and ER(-) (MDA-MB-231) breast cancer cells.
Results
Moderate (2-4 cups/day) to high (≥5 cups/day) coffee intake was associated with smaller invasive primary tumors (Ptrend = 0.013) and lower proportion of ER(+) tumors (Ptrend = 0.018), compared with patients with low consumption (≤1 cup/day). Moderate to high consumption was associated with lower risk for breast cancer events in tamoxifen-treated patients with ER(+) tumors (adjusted HR, 0.51; 95% confidence interval, 0.26-0.97). Caffeine and caffeic acid suppressed the growth of ER(+) (P ≤ 0.01) and ER(-) (P ≤ 0.03) cells. Caffeine significantly reduced ER and cyclin D1 abundance in ER(+) cells. Caffeine also reduced the insulin-like growth factor-I receptor (IGFIR) and pAkt levels in both ER(+) and ER(-) cells. Together, these effects resulted in impaired cell-cycle progression and enhanced cell death.
Conclusions
The clinical and experimental findings demonstrate various anticancer properties of caffeine and caffeic acid against both ER(+) and ER(-) breast cancer that may sensitize tumor cells to tamoxifen and reduce breast cancer growth.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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