Low level laser therapy against radiation induced oral mucositis in elderly head and neck cancer patients-a randomized placebo controlled trial
Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG, Guddattu V
Journal of photochemistry and photobiology. B, Biology · 52 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-02-07 · J Photochem Photobiol B · vol. 144 · págs. 51–56
- Editorial
- Elsevier BV
- Citado
- 78 citas · más que el 86% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, radiation-induced mucositis, head and neck cancer, elderly patients, radiotherapy complications, oral pain, weight loss, tube feeding, He-Ne laser
- MeSH
- humans, head and neck neoplasms, stomatitis, radiation injuries, placebo effect, aged, female, male, low-level light therapy
5 autores
- Ajay Prashad Gautam🇮🇳 · autor de correspondenciaManipal Academy of Higher Education; Kasturba Medical College Hospital; Kasturba Medical College, Manipal
- Donald Fernandes🇮🇳Manipal Academy of Higher Education; Kasturba Medical College Hospital; Kasturba Medical College, Manipal
- Mamidipudi Srinivasa Vidyasagar🇮🇳Manipal Academy of Higher Education
- Arun Gundmi Maiya🇮🇳Manipal Academy of Higher Education
- Vasudeva Guddattu🇮🇳Manipal Academy of Higher Education
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Radiotherapy (RT) is treatment of choice for Elderly Head and Neck Cancer (HNC) patients. Oral mucositis (OM) during RT affects patient's routine oral activities and overall health. Low Level Laser Therapy (LLLT) provided some promising results against cancer therapy induced OM in children and adults. No study specifically evaluated effects of LLLT against RT induced OM in elderly HNC patients until date, hence we did this study.
Material and methods
This double blinded study randomized 46 elderly HNC patients scheduled for RT [Dosage=66 Gray (2 Gy/fraction), 5 fractions/week, total 33 fractions for 6.5 weeks], into laser (22) and placebo (24) groups. Laser group patients received LLLT [Helium-Neon, λ=632.8 nm, power density=0.024 W/cm(2), dosage=3.0 J/point at six anatomical sites bilaterally i.e. 12 locations, total dose/session=36 J, beam aperture diameter=0.6 mm, beam spot size=1 cm(2), irradiated area diameter=1 cm(2), irradiation time/point=125 s, 5 sessions/week, non-contact method-distance between probe and irradiated tissues <1 cm, whereas placebo group did not receive laser. OM grades (RTOG/EORTC Scale), oral pain, weight loss, need for morphine analgesics and tube feeding, and RT break were recorded by a blinded assessor. Descriptive statistics and repeated measures ANOVA were used for analysis keeping p<0.05.
Results
Significant reduction in the incidence and duration of severe OM (p=0.016) and severe pain (p=0.023) and weight loss (p=0.004) was observed in laser than placebo group. No difference was found for enteral feeding use (p=0.667) between two groups.
Conclusions
LLLT decreased the severity of OM and oral pain in elderly HNC patients. Also, lesser weight loss, morphine analgesic use and radiation break happened in laser group.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.