Caffeine intake from coffee or tea and cognitive disorders: a meta-analysis of observational studies
Kim YS, Kwak SM, Myung SK
Neuroepidemiology · 48 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-01-01 · Neuroepidemiology · vol. 44 · número 1 · págs. 51–63
- Editorial
- Karger Publishers
- Citado
- 66 citas · más que el 76% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Tea Polyphenols and Effects · Heavy Metals in Plants
- Palabras clave
- Medicine, Meta-analysis, Dementia, Odds ratio, Confidence interval, Subgroup analysis, Relative risk, Cohort study, Epidemiology, Cognitive decline, Internal medicine, Observational study, Caffeine, Disease
- MeSH
- humans, dementia, alzheimer disease, caffeine, risk, case-control studies, cohort studies, cognition disorders, coffee, tea
3 autores
- Young Seok Kim🇰🇷Seoul National University Hospital
- Sang Mi Kwak🇰🇷Kangbuk Samsung Hospital; Sungkyunkwan University
- Seung‐Kwon Myung
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Observational epidemiological studies such as cross-sectional, case-control, and cohort studies have reported inconsistent findings regarding the association between caffeine intake from coffee or tea and the risk of cognitive disorders such as dementia, Alzheimer's disease, cognitive impairment, and cognitive decline.
Methods
We searched PubMed and EMBASE in September 2014. Three evaluators independently extracted and reviewed articles, based on predetermined selection criteria.
Results
Out of 293 articles identified through the search and bibliographies of relevant articles, 20 epidemiological studies from 19 articles, which involved 31,479 participants (8,398 in six cross-sectional studies, 4,601 in five case-control studies, and 19,918 in nine cohort studies), were included in the final analysis. The pooled odds ratio (OR) or relative risk (RR) of caffeine intake from coffee or tea for cognitive disorders (dementia, Alzheimer's disease, cognitive impairment, and cognitive decline) was 0.82 (95% confidence interval [CI], 0.67-1.01, I² = 63.2%) in a random-effects meta-analysis. In the subgroup meta-analysis by caffeine sources, the summary OR or RR of coffee intake was 0.83 (95% CI, 0.70-0.98; I² = 44.8%). However, in the subgroup meta-analysis by study design, the summary estimates (RR or OR) of coffee intake for cognitive disorders were 0.70 (95% CI, 0.50-0.98; I² = 42.0%) for cross-sectional studies, 0.82 (95% CI, 0.55-1.24; I² = 33.4%) for case-control studies, and 0.90 (95% CI, 0.59-1.36; I² = 60.0%) for cohort studies.
Conclusions
This meta-analysis found that caffeine intake from coffee or tea was not associated with the risk of cognitive disorders.
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