Financiado en parte por All Japan Coffee Association
Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects
Noguchi K, Matsuzaki T, Sakanashi M, Hamadate N, Uchida T, Kina-Tanada M, Kubota H, Nakasone J, Sakanashi M, Ueda S, Masuzaki H, Ishiuchi S, Ohya Y, Tsutsui M
Journal of pharmacological sciences · 41 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- All Japan Coffee Association
- Gobierno
- Japan Society for the Promotion of Science
- Gobierno
- Japan Ministry of Education
- Subvenciones
- Japan Society for the Promotion of Science (15H00594); Japan Society for the Promotion of Science (24590324)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2015-01-27 · J Pharmacol Sci · vol. 127 · número 2 · págs. 217–222
- Editorial
- Elsevier BV
- Citado
- 63 citas · más que el 96% de estudios similares · 5.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Coffee research and impacts · Thermoregulation and physiological responses · Nutritional Studies and Diet
- Palabras clave
- Caffeine, Crossover study, Medicine, Reactive hyperemia, Placebo, Blood pressure, Blood flow, Ingestion, Heart rate, Cardiology, Anesthesia, Physiology, Internal medicine, Pathology
- MeSH
- fingers, endothelium, vascular, microcirculation, humans, caffeine, laser-doppler flowmetry, cross-over studies, double-blind method, placebo effect, blood pressure, regional blood flow, coffee, adult, female, male, young adult, healthy volunteers
14 autores
- Katsuhiko Noguchi🇯🇵 · autor de correspondenciaUniversity of the Ryukyus
- Toshihiro Matsuzaki🇯🇵University of the Ryukyus
- Mayuko Sakanashi🇯🇵University of the Ryukyus
- Naobumi Hamadate🇯🇵University of the Ryukyus
- Taro Uchida🇯🇵University of the Ryukyus
- Mika Kina-Tanada🇯🇵University of the Ryukyus
- Haruaki Kubota🇯🇵University of the Ryukyus
- Junko Nakasone🇯🇵University of the Ryukyus
- Matao Sakanashi🇯🇵University of the Ryukyus
- Shinichiro Ueda🇯🇵University of the Ryukyus
- Hiroaki Masuzaki🇯🇵University of the Ryukyus
- Shogo Ishiuchi🇯🇵University of the Ryukyus
- Yusuke Ohya🇯🇵University of the Ryukyus
- Masato Tsutsui🇯🇵 · autor de correspondenciaUniversity of the Ryukyus
Resumen
El texto original del estudio, en el idioma en que se publicó.
Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in healthy subjects. A double-blind, placebo-controlled, crossover study was performed in 27 healthy volunteers. A cup of either caffeinated or decaffeinated coffee was drunk by the subjects, and reactive hyperemia of finger blood flow was assessed by laser Doppler flowmetry. In an interval of more than 2 days, the same experimental protocol was repeated with another coffee in a crossover manner. Caffeinated coffee intake slightly but significantly elevated blood pressure and decreased finger blood flow as compared with decaffeinated coffee intake. There was no significant difference in heart rate between caffeinated and decaffeinated coffee intake. Importantly, caffeinated coffee intake significantly enhanced post-occlusive reactive hyperemia of finger blood flow, an index of microvascular endothelial function, compared with decaffeinated coffee intake. These results provide the first evidence that caffeine contained in a cup of coffee enhances microvascular function in healthy individuals.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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