Financiado en parte por DSM Nutritional Products
Docosahexaenoic acid and adult memory: a systematic review and meta-analysis
Yurko-Mauro K, Alexander DD, Van Elswyk ME
PloS one · 139 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- DSM Nutritional Products
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-03-18 · PLoS One · vol. 10 · número 3 · pág. e0120391
- Editorial
- Public Library of Science
- Citado
- 216 citas · más que el 95% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Dementia and Cognitive Impairment Research · Nutritional Studies and Diet
- Palabras clave
- docosahexaenoic acid, eicosapentaenoic acid, n-3 long-chain polyunsaturated fatty acids, memory, episodic memory, working memory, semantic memory, omega-3 supplementation, healthy adults, aging, cognitive function
- MeSH
- humans, docosahexaenoic acids, eicosapentaenoic acid, memory, drug interactions, adult, clinical trials as topic, observational studies as topic
3 autores
- Karin Yurko‐Mauro · autor de correspondencia
- Dominik D. Alexander
- Mary E. Van Elswyk
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Subjective memory complaints are common with aging. Docosahexaenoic acid (DHA; 22:6 n-3) is a long-chain polyunsaturated fatty acid (LCPUFA) and an integral part of neural membrane phospholipids that impacts brain structure and function. Past research demonstrates a positive association between DHA plasma status/dietary intake and cognitive function.
Objectives
The current meta-analysis was designed to determine the effect of DHA intake, alone or combined with eicosapentaenoic acid (EPA; 20:5 n-3), on specific memory domains: episodic, working, and semantic in healthy adults aged 18 years and older. A secondary objective was to systematically review/summarize the related observational epidemiologic literature.
Methods
A systematic literature search of clinical trials and observational studies that examined the relationship between n-3 LCPUFA on memory outcomes in healthy adults was conducted in Ovid MEDLINE and EMBASE databases. Studies of subjects free of neurologic disease at baseline, with or without mild memory complaints (MMC), were included. Random effects meta-analyses were conducted to generate weighted group mean differences, standardized weighted group mean differences (Hedge's g), z-scores, and p-values for heterogeneity comparing DHA/EPA to a placebo. A priori sub-group analyses were conducted to evaluate the effect of age at enrollment, dose level, and memory type tested.
Results
Episodic memory outcomes of adults with MMC were significantly (P 1 g/day DHA/EPA improved episodic memory (P<.04). Semantic and working memory changes from baseline were significant with DHA but no between group differences were detected. Observational studies support a beneficial association between intake/blood levels of DHA/EPA and memory function in older adults.
Conclusion
DHA, alone or combined with EPA, contributes to improved memory function in older adults with mild memory complaints.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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