Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation
Shah N, Singh R, Sarangi U, Saxena N, Chaudhary A, Kaur G, Kaul SC, Wadhwa R
PloS one · 35 citas
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- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Education, Culture, Sports, Science and Technology
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-03-19 · PLoS One · vol. 10 · número 3 · pág. e0120554
- Editorial
- Public Library of Science
- Citado
- 69 citas · más que el 99% de estudios similares · 16.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection · Pharmacology and Nanomedicine Research
- Palabras clave
- Neuroprotection, Oxidative stress, In vivo, Pharmacology, Biology, In vitro, Chemistry, Traditional medicine, Biochemistry, Medicine, Biotechnology
- MeSH
- cell line, tumor, animals, humans, rats, withania, plant leaves, hydrogen peroxide, glutamic acid, neuroprotective agents, plant extracts, microscopy, fluorescence, apoptosis, cell differentiation, cell survival, oxidative stress
8 autores
- Navjot Shah🇯🇵National Institute of Advanced Industrial Science and Technology
- Rumani Singh🇯🇵National Institute of Advanced Industrial Science and Technology
- Upasana Sarangi🇯🇵National Institute of Advanced Industrial Science and Technology
- Nishant Saxena🇯🇵National Institute of Advanced Industrial Science and Technology
- Anupama Chaudhary🇯🇵National Institute of Advanced Industrial Science and Technology
- Gurcharan Kaur🇮🇳Guru Nanak Dev University
- Sunil C. Kaul🇯🇵 · autor de correspondenciaNational Institute of Advanced Industrial Science and Technology
- Renu Wadhwa🇯🇵 · autor de correspondenciaNational Institute of Advanced Industrial Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Ashwagandha, a traditional Indian herb, has been known for its variety of therapeutic activities. We earlier demonstrated anticancer activities in the alcoholic and water extracts of the leaves that were mediated by activation of tumor suppressor functions and oxidative stress in cancer cells. Low doses of these extracts were shown to possess neuroprotective activities in vitro and in vivo assays.
Methodology/principal findings
We used cultured glioblastoma and neuroblastoma cells to examine the effect of extracts (alcoholic and water) as well as their bioactive components for neuroprotective activities against oxidative stress. Various biochemical and imaging assays on the marker proteins of glial and neuronal cells were performed along with their survival profiles in control, stressed and recovered conditions. We found that the extracts and one of the purified components, withanone, when used at a low dose, protected the glial and neuronal cells from oxidative as well as glutamate insult, and induced their differentiation per se. Furthermore, the combinations of extracts and active component were highly potent endorsing the therapeutic merit of the combinational approach.
Conclusion
Ashwagandha leaf derived bioactive compounds have neuroprotective potential and may serve as supplement for brain health.
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