Reduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attention Deficit/Hyperactivity Disorder
Bos DJ, Oranje B, Veerhoek ES, Van Diepen RM, Weusten JM, Demmelmair H, Koletzko B, de Sain-van der Velden MG, Eilander A, Hoeksma M, Durston S
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 80 citas
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- Financiación independiente
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Publicación
- Publicado
- 2015-03-19 · Neuropsychopharmacology · vol. 40 · número 10 · págs. 2298–2306
- Editorial
- Springer Nature
- Citado
- 110 citas · más que el 99% de estudios similares · 11.2× el promedio de su campo
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- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Fatty Acid Research and Health · Attention Deficit Hyperactivity Disorder · Developmental and Educational Neuropsychology
- Palabras clave
- attention deficit hyperactivity disorder, omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, dietary supplementation, inattention, cognitive control, boys, homovanillic acid, non-pharmacological treatment
- MeSH
- brain, humans, oxygen, homovanillic acid, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, margarine, magnetic resonance imaging, treatment outcome, analysis of variance, case-control studies, follow-up studies, double-blind method, attention deficit disorder with hyperactivity, neuropsychological tests, dietary supplements, image processing, computer-assisted, adolescent, child, male, surveys and questionnaires
11 autores
- Dienke J. Bos🇳🇱 · autor de correspondenciaUniversity Medical Center Utrecht
- Bob Oranje🇳🇱University Medical Center Utrecht
- E Sanne Veerhoek🇳🇱University Medical Center Utrecht
- Rosanne Maria van Diepen🇳🇱University Medical Center Utrecht
- Juliette Weusten🇳🇱University Medical Center Utrecht
- Hans Demmelmair🇩🇪Ludwig-Maximilians-Universität München
- Berthold Viktor Koletzko🇩🇪Ludwig-Maximilians-Universität München
- Monique G.M. de Sain–van der Velden🇳🇱University Medical Center Utrecht; Wilhelmina Children's Hospital
- Ans Eilander🇳🇱Unilever Research and Development Vlaardingen
- Marco R. Hoeksma🇳🇱Unilever Research and Development Vlaardingen
- Sarah Durston🇳🇱University Medical Center Utrecht
Resumen
El texto original del estudio, en el idioma en que se publicó.
Attention deficit/hyperactivity disorder (ADHD) is one of the most common child psychiatric disorders, and is often treated with stimulant medication. Nonpharmacological treatments include dietary supplementation with omega-3 fatty acids, although their effectiveness remains to be shown conclusively. In this study, we investigated the effects of dietary omega-3 fatty acid supplementation on ADHD symptoms and cognitive control in young boys with and without ADHD. A total of 40 boys with ADHD, aged 8-14 years, and 39 matched, typically developing controls participated in a 16-week double-blind randomized placebo-controlled trial. Participants consumed 10 g of margarine daily, enriched with either 650 mg of eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) each or placebo. Baseline and follow-up assessments addressed ADHD symptoms, fMRI of cognitive control, urine homovanillic acid, and cheek cell phospholipid sampling. EPA/DHA supplementation improved parent-rated attention in both children with ADHD and typically developing children. Phospholipid DHA level at follow-up was higher for children receiving EPA/DHA supplements than placebo. There was no effect of EPA/DHA supplementation on cognitive control or on fMRI measures of brain activity. This study shows that dietary supplementation with omega-3 fatty acids reduces symptoms of ADHD, both for individuals with ADHD and typically developing children. This effect does not appear to be mediated by cognitive control systems in the brain, as no effect of supplementation was found here. Nonetheless, this study offers support that omega-3 supplementation may be an effective augmentation for pharmacological treatments of ADHD (NCT01554462: The Effects of EPA/DHA Supplementation on Cognitive Control in Children with ADHD; http://clinicaltrials.gov/show/NCT01554462).
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