Red meat, dairy, and insulin sensitivity: a randomized crossover intervention study
Turner KM, Keogh JB, Clifton PM
The American journal of clinical nutrition · 45 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of South Australia
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Gobierno
- South Australian Cardiovascular Research Development Program Fellowship
- Gobierno
- National Health and Medical Research Council Principal Research Fellowship
- Universidad u hospital
- University of South Australia Postgraduate Award
Según 6 financiadores declarados.
Publicación
- Publicado
- 2015-03-26 · Am J Clin Nutr · vol. 101 · número 6 · págs. 1173–1179
- Editorial
- Elsevier BV
- Citado
- 58 citas · más que el 98% de estudios similares · 8.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Diet, Metabolism, and Disease · Fatty Acid Research and Health
- Palabras clave
- red meat, dairy products, insulin sensitivity, insulin resistance, type 2 diabetes risk, low-fat dairy, impaired glucose tolerance, impaired fasting glucose, sex differences, overweight and obesity, dietary intervention, C-peptide
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, obesity, insulin, blood glucose, glucose tolerance test, body mass index, diet, fasting, nutrition assessment, cross-over studies, feeding behavior, energy intake, dairy products, meat, adult, middle aged, diet records, female, male, overweight
3 autores
- Kirsty Turner🇦🇺University of South Australia
- Jennifer Beatrice Keogh🇦🇺University of South Australia
- Peter Marshall Clifton🇦🇺 · autor de correspondenciaUniversity of South Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiologic studies have linked high consumption of red and processed meat with risk of developing type 2 diabetes, whereas high dairy consumption has been associated with decreased risk, but interventions have been limited.
Objective
We compared the effects on insulin sensitivity of consuming a diet high in lean red meat with minimal dairy, a diet high in primarily low-fat dairy (from milk, yogurt, or custard) with no red meat, and a control diet that contained neither red meat nor dairy.
Design
A randomized crossover study was undertaken with 47 overweight and obese men and women divided into 2 groups as follows: those with normal glucose tolerance and those with impaired fasting glucose or impaired glucose tolerance. Participants followed the 3 weight-stable dietary interventions for 4 wk with glucose, insulin, and C-peptide measured by using oral-glucose-tolerance tests at the end of each diet.
Results
Fasting insulin was significantly higher after the dairy diet than after the red meat diet (P < 0.01) with no change in fasting glucose resulting in a decrease in insulin sensitivity after the high-dairy diet (P < 0.05) as assessed by homeostasis model assessment of insulin resistance (HOMA-IR). A significant interaction between diet and sex was observed such that, in women alone, HOMA-IR was significantly lower after the red meat diet than after the dairy diet (1.33 ± 0.8 compared with 1.71 ± 0.8, respectively; P < 0.01). Insulin sensitivity calculated by using the Matsuda method was 14.7% lower in women after the dairy diet than after the red meat diet (P < 0.01) with no difference between diets in men. C-peptide was not different between diets.
Conclusion
In contrast to some epidemiologic findings, these results suggest that high consumption of dairy reduces insulin sensitivity compared with a diet high in lean red meat in overweight and obese subjects, some of whom had glucose intolerance. This trial was registered at the Australian New Zealand Clinical Trials Registry as ACTRN12613000441718.
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