Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
Pérez-López FR, Pasupuleti V, Mezones-Holguin E, Benites-Zapata VA, Thota P, Deshpande A, Hernandez AV
Fertility and sterility · 212 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-04-14 · Fertil Steril · vol. 103 · número 5 · págs. 1278–1288.e4
- Editorial
- Elsevier BV
- Citado
- 315 citas · más que el 98% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 73 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Birth, Development, and Health · Vitamin K Research Studies
- Palabras clave
- vitamin D supplementation, pregnancy, 25-hydroxyvitamin D, birth weight, birth length, preeclampsia, gestational diabetes mellitus, small for gestational age, low birth weight, preterm birth, cesarean section, maternal outcomes, neonatal outcomes
- MeSH
- humans, pregnancy complications, vitamin d deficiency, birth weight, vitamin d, treatment outcome, prenatal care, odds ratio, risk factors, chi-square distribution, pregnancy, dietary supplements, infant, newborn, female, randomized controlled trials as topic, biomarkers
7 autores
- Faustino Ramón Pérez-López🇪🇸 · autor de correspondenciaUniversidad de Zaragoza; Hospital Clínico Universitario Lozano Blesa
- Vinay Pasupuleti🇺🇸Case Western Reserve University
- Edward Mezones‐Holguín🇵🇪Peruvian University of Applied Sciences; Instituto Nacional de Salud
- Vicente Aleixandre Benites-Zapata🇵🇪Instituto Nacional de Salud
- Priyaleela Thota🇺🇸Case Western Reserve University
- Abhishek Deshpande🇺🇸Cleveland Clinic
- Adrián Vladimir Hernández🇵🇪🇺🇸Peruvian University of Applied Sciences; Cleveland Clinic
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To assess the effects of vitamin D supplementation during pregnancy on obstetric outcomes and birth variables.
Design
Systematic review and meta-analysis of randomized controlled trials (RCTs).
Setting
Not applicable.
Patient(s)
Pregnant women and neonates.
Intervention(s)
PubMed and 5 other research databases were searched through March 2014 for RCTs evaluating vitamin D supplementation ± calcium/vitamins/ferrous sulfate vs. a control (placebo or active) during pregnancy.
Main outcome measure(s)
Measures were: circulating 25-hydroxyvitamin D [25(OH)D] levels, preeclampsia, gestational diabetes mellitus (GDM), small for gestational age (SGA), low birth weight, preterm birth, birth weight, birth length, cesarean section. Mantel-Haenszel fixed-effects models were used, owing to expected scarcity of outcomes. Effects were reported as relative risks and their 95% confidence intervals (CIs).
Result(s)
Thirteen RCTs (n = 2,299) were selected. Circulating 25(OH)D levels were significantly higher at term, compared with the control group (mean difference: 66.5 nmol/L, 95% CI 66.2-66.7). Birth weight and birth length were significantly greater for neonates in the vitamin D group; mean difference: 107.6 g (95% CI 59.9-155.3 g) and 0.3 cm (95% CI 0.10-0.41 cm), respectively. Incidence of preeclampsia, GDM, SGA, low birth weight, preterm birth, and cesarean section were not influenced by vitamin D supplementation. Across RCTs, the doses and types of vitamin D supplements, gestational age at first administration, and outcomes were heterogeneous.
Conclusion(s)
Vitamin D supplementation during pregnancy was associated with increased circulating 25(OH)D levels, birth weight, and birth length, and was not associated with other maternal and neonatal outcomes. Larger, better-designed RCTs evaluating clinically relevant outcomes are necessary to reach a definitive conclusion.
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