Withania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis
Durg S, Dhadde SB, Vandal R, Shivakumar BS, Charan CS
The Journal of pharmacy and pharmacology · 74 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-04-02 · J Pharm Pharmacol · vol. 67 · número 7 · págs. 879–899
- Editorial
- Oxford University Press
- Citado
- 106 citas · más que el 88% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Andrographolide Research and Applications · Medicinal Plants and Neuroprotection
- Palabras clave
- Withania somnifera, Oxidative stress, Superoxide dismutase, Glutathione peroxidase, Medicine, Lipid peroxidation, Neuroprotection, Pharmacology, Glutathione, Neuroscience, Biochemistry, Pathology, Internal medicine, Chemistry, Psychology, Enzyme
- MeSH
- brain, animals, humans, rodentia, withania, nervous system diseases, drugs, chinese herbal, oxidative stress
5 autores
- Sharanbasappa Durg · autor de correspondencia
- Shivsharan Basavraj Dhadde
- Ravichandra Vandal🇺🇸Grace College & Seminary
- Badamaranahalli S Shivakumar
- C.S. Charan🇨🇾KES College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Withania somnifera has been in use for several thousand years in Ayurveda to treat various neurological disorders. There is, however, not much scientific data on its protective role in neuronal pathology specifically against brain oxidative stress. Hence, an attempt is made in this work for systematic review and meta-analysis of W. somnifera on neurobehavioural disorders induced by brain oxidative stress in rodents.
Methods
A systematic search of the effect of W. somnifera on brain oxidative stress-induced neuronal pathology was performed using electronic databases. The systematic review was performed on neurobehavioural parameters, whereas meta-analysis of W. somnifera effect was done on oxidative stress markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione and lipid peroxidation), nitrite, protein carbonyl, AchE, ChAT and Ach of rodent brain. Data were analysed using Review Manager Software.
Key findings
Twenty-eight studies were selected based upon the inclusion and exclusion criteria. W. somnifera appreciably inhibited the neurological abnormalities due to oxidative stress in rodent brain produced by different physical and chemical stimuli. W. somnifera also significantly restored the altered oxidative and other stress markers in different parts of rodent brain.
Summary
The systematic review provides scientific evidence for the traditional claim of W. somnifera use in different neurological aliments. However, future clinical trials are mandated to establish the therapeutic efficacy and safety in human beings.
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