Nut consumption on all-cause, cardiovascular, and cancer mortality risk: a systematic review and meta-analysis of epidemiologic studies
Grosso G, Yang J, Marventano S, Micek A, Galvano F, Kales SN
The American journal of clinical nutrition · 141 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- International Ph.D. Program in Neuropharmacology, University of Catania Medical School
Según 1 financiador declarado.
Publicación
- Publicado
- 2015-02-05 · Am J Clin Nutr · vol. 101 · número 4 · págs. 783–793
- Editorial
- Elsevier BV
- Citado
- 225 citas · más que el 98% de estudios similares · 5.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Alcohol Consumption and Health Effects
- Palabras clave
- nut consumption, all-cause mortality, cardiovascular mortality, cancer mortality, coronary artery disease, stroke, confounding factors, body mass index, smoking, fruit and vegetable intake, alcohol consumption, dose-response relationship
- MeSH
- humans, fruit, nuts, vegetables, neoplasms, cardiovascular diseases, cause of death, risk factors
6 autores
- Giuseppe Grosso🇺🇸🇵🇱🇮🇹 · autor de correspondenciaTufts University; Cambridge Health Alliance; Jagiellonian University; Harvard University; St. Elizabeth's Medical Center; University of Catania
- Justin Yang🇺🇸🇵🇱🇮🇹Tufts University; Cambridge Health Alliance; Jagiellonian University; Harvard University; St. Elizabeth's Medical Center; University of Catania
- Stefano Marventano🇺🇸🇵🇱🇮🇹Tufts University; Cambridge Health Alliance; Jagiellonian University; Harvard University; St. Elizabeth's Medical Center; University of Catania
- Agnieszka Micek🇺🇸🇵🇱🇮🇹Tufts University; Cambridge Health Alliance; Jagiellonian University; Harvard University; St. Elizabeth's Medical Center; University of Catania
- Fabio Galvano🇺🇸🇵🇱🇮🇹Tufts University; Cambridge Health Alliance; Jagiellonian University; Harvard University; St. Elizabeth's Medical Center; University of Catania
- Stefanos N. Kales🇺🇸🇵🇱🇮🇹Tufts University; Cambridge Health Alliance; Jagiellonian University; Harvard University; St. Elizabeth's Medical Center; University of Catania
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Recent pooled analyses supported a beneficial impact of nut consumption on health, but to our knowledge, whether nuts are associated with overall decreased mortality has not been previously reviewed.
Objectives
We aimed to systematically review prospective studies that explored the effects of nut consumption on all-cause, cardiovascular disease (CVD), and cancer mortality and quantify the size effect through a meta-analysis. We also reviewed confounding factors associated with nut consumption to assess potential clustering with other covariates.
Design
We searched PubMed and EMBASE for studies published up to June 2014. Study characteristics, HRs, and 95% CIs were generated on the basis of quantitative analyses. A dose-response analysis was performed when data were available.
Results
Seven studies for all-cause mortality, 6 studies for CVD mortality, and 2 studies for cancer mortality were included in the meta-analysis with a total of 354,933 participants, 44,636 cumulative incident deaths, and 3,746,534 cumulative person-years. Nut consumption was associated with some baseline characteristics such as lower body mass index and smoking status as well as increased intakes of fruit, vegetables, and alcohol. One-serving of nuts per week and per day resulted in 4% (RR: 0.96; 95% CI: 0.93, 0.98) and 27% (RR: 0.73; 95% CI: 0.60, 0.88) decreased risk of all-cause mortality, respectively, and decreased risk of CVD mortality [RR: 0.93 (95% CI: 0.88, 0.99) and 0.61 (95% CI: 0.42, 0.91), respectively]. Effects were primarily driven by decreased coronary artery disease deaths rather than stroke deaths. Nut consumption was also associated with decreased risk of cancer deaths when highest compared with lowest categories of intake were compared (RR: 0.86; 95% CI: 0.75, 0.98), but no dose-effect was shown.
Conclusion
Nut consumption is associated with lower risk of all-cause, CVD, and cancer mortality, but the presence of confounding factors should be taken into account when considering such findings.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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