Association of cholesterol with risk of pancreatic cancer: a meta-analysis
Wang J, Wang WJ, Zhai L, Zhang DF
World journal of gastroenterology · 48 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-01-01 · World J Gastroenterol · vol. 21 · número 12 · pág. 3711
- Editorial
- Baishideng Publishing Group
- Citado
- 70 citas · más que el 36% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Cancer, Lipids, and Metabolism · Pancreatic and Hepatic Oncology Research · Pancreatitis Pathology and Treatment
- Palabras clave
- Medicine, Meta-analysis, Pancreatic cancer, Internal medicine, Relative risk, Subgroup analysis, Confidence interval, Cohort study, Cholesterol, Cancer, Gastroenterology
- MeSH
- humans, pancreatic neoplasms, hypercholesterolemia, cholesterol, dietary, prognosis, odds ratio, risk assessment, risk factors, aged, middle aged, female, male
1 autor
- Jia Hao Wang · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
To evaluate the effect of dietary cholesterol and serum total cholesterol (TC) on the risk of pancreatic cancer.
Methods
A literature search was performed up to June 2014 in PubMed, EMBASE, China National Knowledge Infrastructure and China Biology Medical literature database for relevant articles published in English or Chinese. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated with a random-effects model.
Results
We included 14 published articles with 439355 participants for dietary cholesterol, and 6 published articles with 1805697 participants for serum TC. For the highest vs lowest category of dietary cholesterol, the pooled RR (95%CI) of pancreatic cancer was 1.308 (1.097-1.559). After excluding two studies (RR > 3.0), the pooled RR (95%CI) was 1.204 (1.050-1.380). In subgroup analysis stratified by study design, the pooled RRs (95%CIs) were 1.523 (1.226-1.893) for case-control studies and 1.023 (0.871-1.200) for cohort studies. The association of dietary cholesterol with the risk of pancreatic cancer was significant for studies conducted in North America [1.275 (1.058-1.537)] and others [2.495 (1.565-3.977)], but not in Europe [1.149 (0.863-1.531)]. No significant association [1.003 (0.859-1.171)] was found between the risk of pancreatic cancer and serum TC.
Conclusion
Dietary cholesterol may be associated with an increased risk of pancreatic cancer in worldwide populations, except for Europeans. The results need to be confirmed further.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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