Effect of pistachio nut consumption on endothelial function and arterial stiffness
Kasliwal RR, Bansal M, Mehrotra R, Yeptho KP, Trehan N
Nutrition (Burbank, Los Angeles County, Calif.) · 50 citas
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Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-11-07 · Nutrition · vol. 31 · número 5 · págs. 678–685
- Editorial
- Elsevier BV
- Citado
- 86 citas · más que el 95% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Cardiovascular Health and Disease Prevention · Nutritional Studies and Diet
- Palabras clave
- pistachio nuts, endothelial function, arterial stiffness, pulse wave velocity, flow-mediated dilation, dyslipidemia, lifestyle modification, HDL cholesterol, LDL cholesterol, fasting blood glucose, vascular health, nut consumption, brachial artery, oxidative stress, lipid profile, glycemic control
- MeSH
- brachial artery, carotid arteries, femoral artery, endothelium, vascular, humans, pistacia, cholesterol, blood glucose, lipoproteins, hdl, lipoproteins, ldl, blood flow velocity, treatment outcome, fasting, life style, vasodilation, adult, middle aged, female, male, ankle brachial index, vascular stiffness, pulse wave analysis
5 autores
- Ravi Ratan Kasliwal🇮🇳Medanta The Medicity; Medanta The Medicity
- Manish Bansal🇮🇳 · autor de correspondenciaMedanta The Medicity; Medanta The Medicity
- Rahul Mehrotra🇮🇳Medanta The Medicity; Medanta The Medicity
- Kajal Yeptho🇮🇳Medanta The Medicity; Medanta The Medicity
- Naresh K. Trehan🇮🇳Medanta The Medicity; Medanta The Medicity
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Previous studies have demonstrated beneficial effects of regular consumption of pistachio nuts on glycemic, lipid, and oxidative stress parameters. The aim of this study was to determine its effect on vascular health, which has not been adequately studied so far.
Methods
In this open label, randomized parallel-group study, 60 adults with mild dyslipidemia were randomized to lifestyle modification (LSM) alone or LSM with consumption of 80 g (in-shell) pistachios (equivalent to 40 g or 1.5 oz shelled pistachios) daily for 3 mo. Biochemical parameters, brachial artery flow-mediated vasodilation (BAFMD), and carotid-femoral and brachial-ankle pulse wave velocity (cfPWV and baPWV, respectively) were measured before and after the intervention.
Results
At 3 mo, there was no change in any of the clinical or biochemical parameters in the LSM group. However, the patients in the pistachio group had a significant increase in high-density lipoprotein cholesterol (HDL-C; 35.7 ± 8.8 mg/dL versus 37.8 ± 10.1 mg/dL; P = 0.04) and a reduction in low-density lipoprotein cholesterol (137.2 ± 32.6 mg/dL versus 127.6 ± 34.0 mg/dL; P = 0.02), total cholesterol (TC)-to-HDL-C ratio (5.8 ± 1.3 mg/dL versus 5.3 ± 1.1 mg/dL; P = 0.001), and fasting blood sugar (88.8 ± 7.1 mg/dL versus 86.6 ± 6.3 mg/dL; P = 0.05). Additionally, whereas LSM alone was associated with no improvement in BAFMD or PWV, individuals in the pistachio group had significant reduction in left baPWV (1261.7 ± 187.5 cm/sec versus 1192.4 ± 152.5 cm/sec; P = 0.02) and statistically nonsignificant improvement in most other parameters, including BAFMD. As a result, at 3 mo the patients in the pistachio group had lower cfPWV (770.9 ± 96.5 cm/sec versus 846.4 ± 162.0 cm/sec; P = 0.08), lower left baPWV (1192.4 ± 152.5 cm/sec versus 1326.3 ± 253.7 cm/sec; P = 0.05), and lower average baPWV (1208.2 ± 118.4 cm/sec versus 1295.8 ± 194.1 cm/sec; P = 0.08) compared with the LSM group. Two-way analysis of variance revealed significant treatment effect of pistachio consumption on cfPWV, left baPWV, average baPWV, and BAFMD (P = 0.037, 0.01, 0.07, and 0.046, respectively).
Conclusions
The present study demonstrates that regular consumption of pistachio nuts not only improves glycemic and lipid parameters, but also results in improvements in vascular stiffness and endothelial function. Importantly, these improvements were seen in apparently healthy individuals and with a diet (including pistachios) and exercise regimen that every adult individual is expected to follow.
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